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AB198005

Anti-DHRS3 antibody

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(1 Publication)

Rabbit Polyclonal DHRS3 antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human DHRS3.

View Alternative Names

RDH17, SDR16C1, UNQ2424/PRO4983, DHRS3, Short-chain dehydrogenase/reductase 3, DD83.1, Retinal short-chain dehydrogenase/reductase 1, Retinol dehydrogenase 17, Short chain dehydrogenase/reductase family 16C member 1, retSDR1

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DHRS3 antibody (AB198005)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DHRS3 antibody (AB198005)

Immunohistochemical analysis of paraffin-embedded Human breast cancer tissue labeling DHRS3 with ab198005 at 1/30 dilution.

Western blot - Anti-DHRS3 antibody (AB198005)
  • WB

Supplier Data

Western blot - Anti-DHRS3 antibody (AB198005)

10% SDS-PAGE.

All lanes:

Western blot - Anti-DHRS3 antibody (ab198005) at 1/550 dilution

Lane 1:

Mouse liver tissue lysate at 40 µg

Lane 2:

A375 cell lysate at 40 µg

Predicted band size: 34 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human DHRS3. The exact immunogen used to generate this antibody is proprietary information.

O75911

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

DHRS3 also known as dehydrogenase/reductase member 3 is an enzyme involved in the redox regulation of retinoid metabolism. This enzyme has a molecular mass of approximately 36 kDa. DHRS3 converts retinaldehyde to retinol by reducing retinal in the presence of NADPH pivotal in maintaining retinoid homeostasis. It is expressed in various tissues including the liver and the central nervous system.
Biological function summary

DHRS3 plays a role in the regulation of cellular differentiation development and vision processes by modulating levels of active retinoids. Although not part of a larger complex it is important for controlling the concentration of retinoic acid precursors. The enzyme helps ensure that retinoic acid levels remain within a range that supports normal cell function and organismal development.

Pathways

DHRS3 is integral to the retinol metabolism pathway and indirectly influences the retinoic acid signaling pathway. Through its activity it balances retinol and retinoic acid levels influencing gene expression related to cell proliferation and apoptosis. This enzyme interacts with proteins such as RDH10 within the pathway to modulate retinoid conversion processes critical for cell fate decisions.

Irregularities in DHRS3 function can contribute to the development of metabolic disorders and retinal diseases. Altered expression of DHRS3 has been associated with conditions like obesity as its activity affects lipid metabolism and energy balance. Moreover its interaction with proteins like ALDH1A1 links it to visual impairments and diseases arising from disrupted retinoic acid synthesis.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Catalyzes the reduction of all-trans-retinal to all-trans-retinol in the presence of NADPH.
See full target information DHRS3
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Scientific reports 7:8649 PubMed28819306

2017

Prognostic Significance of EDIL3 Expression and Correlation with Mesenchymal Phenotype and Microvessel Density in Lung Adenocarcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Dongjun Jeong,Seona Ban,Seunghyun Oh,Su Jin Lee,Seong Yong Park,Young Wha Koh
View all publications
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Product promise

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