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AB236380

Anti-DHRS4L2 antibody [OTI4A10]

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(1 Publication)

Mouse Monoclonal DHRS4L2 antibody. Suitable for WB, IHC-P and reacts with Transfected cell lysate - Human, Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human DHRS4L2.

View Alternative Names

SDR25C3, DHRS4L2, Dehydrogenase/reductase SDR family member 4-like 2, Short chain dehydrogenase/reductase family 25C member 3, Protein SDR25C3

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DHRS4L2 antibody [OTI4A10] (AB236380)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DHRS4L2 antibody [OTI4A10] (AB236380)

Paraffin-embedded human testis tissue stained for DHRS4L2 with ab236380 at a 1/250 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DHRS4L2 antibody [OTI4A10] (AB236380)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DHRS4L2 antibody [OTI4A10] (AB236380)

Paraffin-embedded human placenta tissue stained for DHRS4L2 with ab236380 at a 1/250 dilution in immunohistochemical analysis.

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

OTI4A10

Isotype

IgG2a

Carrier free

No

Reacts with

Mouse, Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human DHRS4L2.

Q6PKH6

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  • 4
  • 1
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/250", "IHCP-species-notes": "<p>Heat-induced epitope retrieval by 1 mM EDTA in 10 mM Tris buffer (pH 8.5) at 120°C for 3 minutes.</p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Transfected cell lysate - Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification
Purification notes
Purified from cell culture supernatant.
Storage buffer
pH: 7.3 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

DHRS4L2 also known as dehydrogenase/reductase (SDR family) member 4 like 2 is a part of the short-chain dehydrogenase/reductase family. Its molecular mass is approximately 30 kDa. This protein is expressed in various tissues with higher concentrations observed in the liver and kidney. The DHRS4L2 protein plays a role in oxidoreductase activity where it contributes to the balance of NAD+/NADH and NADP+/NADPH metabolic co-factors important for numerous enzymatic reactions.
Biological function summary

DHRS4L2 acts by converting substrates through its oxidoreductase function maintaining cellular redox homeostasis. It is not well-characterized as a part of any protein complex but its activity supports the detoxification processes and lipid metabolism within the cell. Through these functions the protein aids in regulating the concentration of vital metabolites and protecting cells from oxidative stress.

Pathways

DHRS4L2 participates in the lipid metabolism pathway and is implicated in maintaining redox homeostasis. It interacts alongside other enzymes involved in the NADP+ and NADPH metabolism pathway including the related protein DHRS4. The protein's activity plays an essential role in the metabolic pathways ensuring the biochemical stability required for proper cell function and energy balance.

DHRS4L2 shows connections to metabolic syndrome and liver diseases. Dysregulated expression of DHRS4L2 has been observed in cases of metabolic syndrome where the dysfunction of lipid metabolism occurs. In liver diseases such as non-alcoholic fatty liver disease its altered activity may exacerbate oxidative stress contributing to disease progression. The protein's interaction with enzymes like DHRS4 is significant in understanding its role in pathophysiological conditions offering insights into potential therapeutic targets.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Probable oxidoreductase.
See full target information DHRS4L2
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Journal of translational medicine 23:805 PubMed40682116

2025

Sinensetin serves as an AMPK activator to inhibit RANKL-induced osteoclastogenesis via osteoclast cytoskeleton reorganization.

Applications

Unspecified application

Species

Unspecified reactive species

Yijie Gao,Rui Zhou,Xixi Lin,Zhijuan Liu,Yuangang Su,Haoyu Lian,Bin Lin,Xiaofei Ding,Shijie Liao,Xiangde Li,Jinmin Zhao,Jiake Xu,Ren Xu,Qian Liu,Fangming Song
View all publications
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Product promise

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For full details, please see our Terms & Conditions

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