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AB126074

Anti-DHRS9 antibody

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(2 Publications)

Rabbit Polyclonal DHRS9 antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human DHRS9 aa 1-300.

View Alternative Names

RDH15, SDR9C4, UNQ835/PRO1773, DHRS9, Dehydrogenase/reductase SDR family member 9, 3-alpha hydroxysteroid dehydrogenase, NADP-dependent retinol dehydrogenase/reductase, RDH-E2, RDHL, Retinol dehydrogenase 15, Short chain dehydrogenase/reductase family 9C member 4, Short-chain dehydrogenase/reductase retSDR8, Tracheobronchial epithelial cell-specific retinol dehydrogenase, 3-alpha-HSD, RDH-TBE

1 Images
Western blot - Anti-DHRS9 antibody (AB126074)
  • WB

Unknown

Western blot - Anti-DHRS9 antibody (AB126074)

10% SDS PAGE

All lanes:

Western blot - Anti-DHRS9 antibody (ab126074) at 1/1000 dilution

Lane 1:

NT2/D1 (human embryonal testis carcinoma cell line) whole cell lysate at 30 µg

Lane 2:

SK-N-SH (human neuroblastoma cell line) whole cell lysate at 30 µg

Predicted band size: 35 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Human DHRS9 aa 1-300. The exact immunogen used to generate this antibody is proprietary information.

Q9BPW9

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

DHRS9 also known as dehydrogenase/reductase SDR family member 9 is an enzyme encoded by the DHRS9 gene. It belongs to the short-chain dehydrogenases/reductases (SDR) family and has a molecular mass of about 34 kDa. This protein acts mainly as an oxidoreductase involved in the metabolism of various substrates including retinoids and xenobiotics. DHRS9 has broad tissue distribution but high expression levels are noted in the liver kidney and placenta.
Biological function summary

As a member of the SDR family DHRS9 plays roles in redox reactions that are important for metabolic functions. It does not typically form complexes with other proteins but cooperates with enzymes such as retinol dehydrogenases. This protein is involved in the conversion of retinol to retinal which is a part of vitamin A metabolism that is essential for vision and cellular differentiation.

Pathways

Several significant metabolic processes involve DHRS9. It is primarily engaged in retinoic acid metabolism influencing retinoid signaling pathways which are vital for embryonic development and homeostasis. In these pathways DHRS9 interacts closely with retinoic acid receptors (RAR) and cellular retinoic acid-binding proteins which regulate gene expression required for cell differentiation and proliferation.

Research connects DHRS9 to specific conditions. Aberrant expression of DHRS9 has been associated with certain liver diseases and cancer types. In cases of liver disease misregulation of DHRS9 affects retinol metabolism impacting liver function and regenerative processes. Studies also suggest linkage between DHRS9 and RARs in oncogenic pathways where altered retinoic acid metabolism may affect tumor suppression mechanisms.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

3-alpha-hydroxysteroid dehydrogenase that converts 3-alpha-tetrahydroprogesterone (allopregnanolone) to dihydroxyprogesterone and 3-alpha-androstanediol to dihydroxyprogesterone (PubMed : 11294878, PubMed : 29541409). Also plays a role in the biosynthesis of retinoic acid from retinaldehyde (PubMed : 11304534, PubMed : 12618084). Can utilize both NADH and NADPH.
See full target information DHRS9
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Analytical cellular pathology (Amsterdam) 2022:8275574 PubMed36340269

2022

Transcription Factor FXR Activates DHRS9 to Inhibit the Cell Oxidative Phosphorylation and Suppress Colon Cancer Progression.

Applications

Unspecified application

Species

Unspecified reactive species

Jinlai Zhao,Yigang Wang,Yang Wang,Jianchao Gao,Haichao Yang,Xiaotang Wu,Hua Li

Molecular medicine reports 14:4119-4123 PubMed27667392

2016

Dysregulation of GTPase IMAP family members in hepatocellular cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Zhen Huang,Wei Zhang,Chunhai Gao,Baoju Ji,Xiuwen Chi,Wei Zheng,Hai Lan Wang
View all publications
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