AB171736

Anti-DHRSX antibody [EPR7753(2)]

RabMAb
Recombinant
What is this?

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(2 Publications)

Rabbit Recombinant Monoclonal DHRSX antibody. Suitable for WB, Flow Cyt (Intra) and reacts with Human samples. Cited in 2 publications.

View Alternative Names

CXorf11, DHRS5X, SDR46C1, SDR7C6, UNQ6508/PRO21433, DHRSX, Polyprenol dehydrogenase, DHRSXY, Dehydrogenase/reductase SDR family member on chromosome X, Dolichal reductase

2 Images

Flow Cytometry (Intracellular) - Anti-DHRSX antibody [EPR7753(2)] (AB171736)

Flow Cyt (Intra)

Supplier Data

Flow Cytometry (Intracellular) - Anti-DHRSX antibody [EPR7753(2)] (AB171736)

Intracellular flow cytometric analysis of permeabilized HepG2 cells labeling DHRSXusingab171736 at 1/10 dilutionor a rabbit IgG (negative) (green).

Supplier Data

Western blot - Anti-DHRSX antibody [EPR7753(2)] (AB171736)

All lanes:

Western blot - Anti-DHRSX antibody [EPR7753(2)] (ab171736) at 1/1000 dilution

Lane 1:

HepG2 cell lysate at 10 µg

Lane 2:

Human fetal liver lysate at 10 µg

Predicted band size: 36 kDa

false

Carrier free

Anti-DHRSX antibody [EPR7753(2)] - BSA and Azide free

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR7753(2)

Isotype

IgG

Carrier free

Reacts with

Human

Applications

WB, Flow Cyt (Intra)

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"}, "FlowCytIntra" : {"fullname" : "Flow Cytometry (Intracellular)", "shortname":"Flow Cyt (Intra)"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "1/10 - 1/100", "IP-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "", "FlowCytIntra-species-checked": "testedAndGuaranteed", "FlowCytIntra-species-dilution-info": "1/10 - 1/100", "FlowCytIntra-species-notes": "<a href='/en-us/products/primary-antibodies/rabbit-igg-monoclonal-epr25a-isotype-control-ab172730'>ab172730</a> - Rabbit monoclonal IgG, is suitable for use as an isotype control with this antibody." }, "Mouse": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "notRecommended", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "", "FlowCytIntra-species-checked": "notRecommended", "FlowCytIntra-species-dilution-info": "", "FlowCytIntra-species-notes": "<a href='/en-us/products/primary-antibodies/rabbit-igg-monoclonal-epr25a-isotype-control-ab172730'>ab172730</a> - Rabbit monoclonal IgG, is suitable for use as an isotype control with this antibody." }, "Rat": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "1/10 - 1/100", "IP-species-notes": "", "WB-species-checked": "notRecommended", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "", "FlowCytIntra-species-checked": "notRecommended", "FlowCytIntra-species-dilution-info": "", "FlowCytIntra-species-notes": "<a href='/en-us/products/primary-antibodies/rabbit-igg-monoclonal-epr25a-isotype-control-ab172730'>ab172730</a> - Rabbit monoclonal IgG, is suitable for use as an isotype control with this antibody." } } }

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Product details

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form

Liquid

Purity

Tissue culture supernatant

Storage buffer

pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

DHRSX (Dehydrogenase/Reductase (SDR Family) Member X) is a protein of interest in various biological studies. It is known for its role in oxidoreductase activity and commonly does not have other alternate names. The protein mass is approximately 37 kDa. DHRSX expresses in multiple tissues with notable expression in the brain and liver suggesting a diverse role across different systems.

Biological function summary

The protein DHRSX affects cellular processes by participating in metabolism. It does not seem to be a part of a larger protein complex indicating its function may rely more on individual activity. Its capability to act in reduction-oxidation reactions helps cells manage oxidative stress and maintain metabolic balance. The effects of DHRSX have implications in normal cellular function and development.

Pathways

DHRSX is important in the metabolic and detoxification pathways. It engages with the NADP/NADPH cofactor system influencing the oxidative status of cells and supporting cellular defense against reactive oxygen species. Additionally the interaction with proteins like ADH1 (Alcohol Dehydrogenase 1) further integrates DHRSX into enzymatic pathways critical for metabolizing alcohols and aldehydes.

DHRSX has potential links to metabolic syndromes and liver disease. Research has found that irregular DHRSX expression correlates with metabolic disorders like obesity possibly through disruption in glucose and lipid metabolism. The protein's activity appears connected to other metabolic proteins such as PPARα (Peroxisome Proliferator-Activated Receptor Alpha) shedding light on how disturbances in DHRSX can contribute to broader metabolic issues.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Oxidoreductase that plays a key role in early steps of protein N-linked glycosylation by mediating two non-consecutive steps in dolichol biosynthesis (PubMed : 38821050). Acts both as a NAD(+)-dependent dehydrogenase and as a NADPH-dependent reductase during the conversion of polyprenol into dolichol (PubMed : 38821050). First catalyzes the NAD(+)-dependent dehydrogenation of polyprenol into polyprenal; polyprenal is then reduced into dolichal by SRD5A3 (PubMed : 38821050). It then catalyzes the NADPH-dependent reduction of dolichal into dolichol (PubMed : 38821050). May also acts as a positive regulator of starvation-induced autophagy (PubMed : 25076851).

See full target information DHRSX

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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Clinical and translational medicine 11:e449 PubMed34185414

2021

Melatonin inhibits lipid accumulation to repress prostate cancer progression by mediating the epigenetic modification of CES1.

Applications

Unspecified application

Species

Unspecified reactive species

Lijie Zhou,Cai Zhang,Xiong Yang,Lilong Liu,Junyi Hu,Yaxin Hou,Hong Tao,Haruhiko Sugimura,Zhaohui Chen,Liang Wang,Ke Chen

Cell death & disease 10:162 PubMed30770791

2019

NETO2 promotes invasion and metastasis of gastric cancer cells via activation of PI3K/Akt/NF-κB/Snail axis and predicts outcome of the patients.

Applications

Unspecified application

Species

Unspecified reactive species

Jun-Yan Liu,Lei Jiang,Tao He,Jia-Jia Liu,Jun-Yan Fan,Xian-Hui Xu,Bo Tang,Yan Shi,Yong-Liang Zhao,Feng Qian,Yan Wang,You-Hong Cui,Pei-Wu Yu

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-DHRSX antibody [EPR7753(2)]

Flow Cytometry (Intracellular) - Anti-DHRSX antibody [EPR7753(2)] (AB171736)

Western blot - Anti-DHRSX antibody [EPR7753(2)] (AB171736)

Related conjugates and formulations (1)

Key facts

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

Immunogen

Complementary Products

Secondary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity data

Product details

Properties and storage information

Form

Purity

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (2)

Product promise