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AB249641

Anti-DHRSX antibody [EPR7753(2)] - BSA and Azide free

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(1 Publication)

Rabbit Recombinant Monoclonal DHRSX antibody. Carrier free. Suitable for WB, Flow Cyt (Intra) and reacts with Human samples. Cited in 1 publication.

View Alternative Names

CXorf11, DHRS5X, SDR46C1, SDR7C6, UNQ6508/PRO21433, DHRSX, Polyprenol dehydrogenase, DHRSXY, Dehydrogenase/reductase SDR family member on chromosome X, Dolichal reductase

2 Images
Flow Cytometry (Intracellular) - Anti-DHRSX antibody [EPR7753(2)] - BSA and Azide free (AB249641)
  • Flow Cyt (Intra)

Supplier Data

Flow Cytometry (Intracellular) - Anti-DHRSX antibody [EPR7753(2)] - BSA and Azide free (AB249641)

This data was developed using ab171736, the same antibody clone in a different buffer formulation.

Intracellular flow cytometric analysis of permeabilized HepG2 cells labeling DHRSX using ab171736 at 1/10 dilution or a rabbit IgG (negative) (green).

Western blot - Anti-DHRSX antibody [EPR7753(2)] - BSA and Azide free (AB249641)
  • WB

Supplier Data

Western blot - Anti-DHRSX antibody [EPR7753(2)] - BSA and Azide free (AB249641)

This data was developed using ab171736, the same antibody clone in a different buffer formulation.

All lanes:

Western blot - Anti-DHRSX antibody [EPR7753(2)] (<a href='/en-us/products/primary-antibodies/dhrsx-antibody-epr77532-ab171736'>ab171736</a>) at 1/1000 dilution

Lane 1:

HepG2 cell lysate at 10 µg

Lane 2:

Human fetal liver lysate at 10 µg

Predicted band size: 36 kDa

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Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR7753(2)

Isotype

IgG

Carrier free

Yes

Reacts with

Human

Applications

WB, Flow Cyt (Intra)

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

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Product details

ab249641 is the carrier-free version of ab171736.

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.

Use our conjugation kits for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.

Compatibility
This product is compatible with the Maxpar® Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar® is a trademark of Fluidigm Canada Inc.

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification
Storage buffer
pH: 7.2 - 7.4 Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
Do Not Freeze
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

DHRSX (Dehydrogenase/Reductase (SDR Family) Member X) is a protein of interest in various biological studies. It is known for its role in oxidoreductase activity and commonly does not have other alternate names. The protein mass is approximately 37 kDa. DHRSX expresses in multiple tissues with notable expression in the brain and liver suggesting a diverse role across different systems.
Biological function summary

The protein DHRSX affects cellular processes by participating in metabolism. It does not seem to be a part of a larger protein complex indicating its function may rely more on individual activity. Its capability to act in reduction-oxidation reactions helps cells manage oxidative stress and maintain metabolic balance. The effects of DHRSX have implications in normal cellular function and development.

Pathways

DHRSX is important in the metabolic and detoxification pathways. It engages with the NADP/NADPH cofactor system influencing the oxidative status of cells and supporting cellular defense against reactive oxygen species. Additionally the interaction with proteins like ADH1 (Alcohol Dehydrogenase 1) further integrates DHRSX into enzymatic pathways critical for metabolizing alcohols and aldehydes.

DHRSX has potential links to metabolic syndromes and liver disease. Research has found that irregular DHRSX expression correlates with metabolic disorders like obesity possibly through disruption in glucose and lipid metabolism. The protein's activity appears connected to other metabolic proteins such as PPARα (Peroxisome Proliferator-Activated Receptor Alpha) shedding light on how disturbances in DHRSX can contribute to broader metabolic issues.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Oxidoreductase that plays a key role in early steps of protein N-linked glycosylation by mediating two non-consecutive steps in dolichol biosynthesis (PubMed : 38821050). Acts both as a NAD(+)-dependent dehydrogenase and as a NADPH-dependent reductase during the conversion of polyprenol into dolichol (PubMed : 38821050). First catalyzes the NAD(+)-dependent dehydrogenation of polyprenol into polyprenal; polyprenal is then reduced into dolichal by SRD5A3 (PubMed : 38821050). It then catalyzes the NADPH-dependent reduction of dolichal into dolichol (PubMed : 38821050). May also acts as a positive regulator of starvation-induced autophagy (PubMed : 25076851).
See full target information DHRSX
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Clinical and experimental pharmacology & physiology 52:e70032 PubMed40069996

2025

Pancreatitis Independently Induced by Hypertriglyceridaemia Outlines the Immune Profiles of HTGP in Clinic.

Applications

Unspecified application

Species

Unspecified reactive species

Jianxing Liu,Caixia Liang,Wenjing Yan,Yanfeng Zhang,Yi Pan,Yue Yang,Fangfang Zhang,Xiaojian Liu,Liang Jin
View all publications
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Product promise

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For full details, please see our Terms & Conditions

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