Anti-dis2 antibody

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Biological function summary

Dis2 acts as an important regulator of the cell cycle and mitotic exit. It often forms part of a complex with other phosphatases ensuring proper timing and sequence in phosphorylation-dephosphorylation events. Dis2’s activity stabilizes important cell cycle proteins by reversing phosphorylation-driven signaling processes. This allows cells to progress smoothly through different stages of division minimizing errors that could otherwise lead to cellular dysfunction or degeneration.

Pathways

Dis2 integrates into cell cycle control and checkpoint pathways working closely with other regulatory proteins like cyclins and cyclin-dependent kinases (CDKs). It participates in the Regulation of Mitotic Exit network ensuring the proper completion of mitosis and cytokinesis. This phosphatase modulates interactions through direct association with proteins such as cyclin B driving cells out of mitotic arrest and into G1 phase. Dis2’s collaboration with cyclin-dependent checkpoint pathways confirms its central role in maintaining the integrity of genomic division.