Anti-DIS3L antibody

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

DIS3L also known as DIS3-like exonuclease 1 is an important protein involved in RNA metabolism. It exhibits 3'-to-5' exonuclease activity playing an important role in degrading RNA molecules within the cell. DIS3L generally has a mass of approximately 110 kDa. It is widely expressed with notable presence in tissues such as the brain liver and kidney. This protein belongs to the RNase II family sharing structural and functional similarities with other exoribonucleases.

Biological function summary

The mechanisms of DIS3L contribute significantly to the RNA exosome complex a multiprotein complex responsible for processing and degrading RNA molecules. This involvement suggests that DIS3L plays a part in the quality control of RNA ensuring the proper turnover and maturation of various RNA species. By participating in the RNA exosome complex DIS3L contributes to critical cellular processes such as gene expression regulation and RNA surveillance.

Pathways

DIS3L integrates into the RNA degradation pathways and the nonsense-mediated mRNA decay (NMD) pathway. These pathways play essential roles in maintaining cellular RNA balance and regulating gene expression. In the RNA degradation pathway DIS3L acts alongside proteins like SKI2 which further highlights its involvement in preserving RNA homeostasis. DIS3L's function within these pathways underlines its importance in controlling aberrant RNA molecules that can influence cell fate and function.

Disruptions in DIS3L activity appear linked to neurodegenerative diseases and specific cancers. Aberrant function of DIS3L within the RNA exosome complex can lead to the accumulation of faulty RNA molecules contributing to disease onset and progression. Glioblastoma an aggressive brain tumor and Alzheimer's disease represent conditions where altered expression and activity of DIS3L have drawn research interest. Connections between DIS3L and other proteins involved in these diseases such as TDP-43 in neurodegeneration and various oncogenic pathways in cancer highlight its potential role in disease pathogenesis.