Anti-DLC1 antibody

Supplementary info

Activity summary

DLC1 also known as Deleted in Liver Cancer 1 is a tumor suppressor protein with a mass of approximately 123 kilodaltons. It functions mechanically as a Rho GTPase-activating protein (RhoGAP) regulating the activity of Rho family GTPases. DLC1 is expressed in various tissues with significant expression in the liver lung and kidney. The protein helps maintain cytoskeletal integrity and cell stability by modulating actin dynamics and cellular contractility.

Biological function summary

The protein DLC1 plays an important role in cell migration proliferation and adhesion. It often forms part of a multi-protein complex with tensin proteins which helps link it to the actin cytoskeleton. Through its GAP activity DLC1 negatively regulates RhoA a small GTPase. This regulation affects cell shape and movement by controlling focal adhesion turnover and stress fiber formation essential processes in maintaining normal cellular architecture.

Pathways

DLC1 impacts cellular signaling related to the cell cycle and apoptosis. It is heavily involved in the regulation of the Rho/Rac signaling pathway which is critical for actin cytoskeleton organization and cellular dynamics. DLC1 interacts with proteins such as RhoA and Cdc42 within these pathways facilitating signal transduction that affects cellular responses to external stimuli and internal checkpoints ensuring proper cell division and programmed cell death.

Associated diseases and disorders

DLC1 is closely related to various cancers including liver and breast cancer. Its tumor suppressor function is often lost or reduced in these conditions leading to unchecked cellular proliferation and metastasis. In the context of liver cancer DLC1 interacts with proteins such as PTEN influencing tumor growth and progression. Aberrations in DLC1 expression or activity can also correlate with other disorders involving disrupted cell signaling and cytoskeletal abnormalities.