Anti-DLGAP2 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

DLGAP2 also known as Discs Large Associated Protein 2 plays a structural role in synapses. It's an 110 kDa protein found primarily in the brain specifically within the postsynaptic density of neurons. DLGAP2 interacts with other synaptic proteins to scaffold and stabilize neurotransmitter receptors. Its expression is notable in regions like the cerebral cortex hippocampus and striatum emphasizing its importance in neurotransmission and synaptic plasticity.

Biological function summary

DLGAP2 functions are part of the synaptic signaling complex. It works closely with other proteins such as PSD-95 and SAPAP. These interactions help organize postsynaptic components essential for signal transduction and neuronal communication. By facilitating proper synapse organization DLGAP2 contributes to maintaining the efficiency of nerve signal transmission.

Pathways

DLGAP2 significantly influences synaptic signaling and plasticity. It integrates into pathways like the NMDA receptor signaling pathway interacting with proteins such as PSD-95 and SAP90. These connections allow DLGAP2 to regulate synaptic strength and plasticity which are fundamental for learning and memory processes.

Associated diseases and disorders

Current research points to associations of DLGAP2 with autism spectrum disorders and schizophrenia. DLGAP2 abnormalities may affect synaptic organization and function contributing to the pathophysiology of these conditions. Through these pathways it interacts with proteins like Shank3 and neuroligins which are also implicated in neurodevelopmental and psychiatric disorders.