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AB106520

Anti-DLGAP2 antibody

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(2 Publications)

Rabbit Polyclonal DLGAP2 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human DLGAP2.

View Alternative Names

C8orf68, DAP2, ERICH1-AS1, DLGAP2, Disks large-associated protein 2, DAP-2, PSD-95/SAP90-binding protein 2, SAP90/PSD-95-associated protein 2, SAPAP2

3 Images
Immunocytochemistry/ Immunofluorescence - Anti-DLGAP2 antibody (AB106520)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-DLGAP2 antibody (AB106520)

Immunofluorescence of SAPAP2 in Human Brain cells using ab106520 at 20 ug/ml.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DLGAP2 antibody (AB106520)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DLGAP2 antibody (AB106520)

Immunohistochemistry of SAPAP2 in human brain with SAPAP2 antibody ab106520 at 5 μg/mL.

Western blot - Anti-DLGAP2 antibody (AB106520)
  • WB

Supplier Data

Western blot - Anti-DLGAP2 antibody (AB106520)

Lane 1:

Western blot - Anti-DLGAP2 antibody (ab106520) at 0.5 µg/mL

Lane 2:

Western blot - Anti-DLGAP2 antibody (ab106520) at 1 µg/mL

All lanes:

Raji (human Burkitt's lymphoma cell line) cell lysate

Predicted band size: 117 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, ICC/IF, IHC-P

applications

Immunogen

Synthetic Peptide within Human DLGAP2. The exact immunogen used to generate this antibody is proprietary information.

Q9P1A6

Specificity

ab106520 will not cross-react with other SAPAP proteins.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-1 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5 µg/mL", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "20 µg/mL", "ICCIF-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
Up to 12 months
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

DLGAP2 also known as Discs Large Associated Protein 2 plays a structural role in synapses. It's an 110 kDa protein found primarily in the brain specifically within the postsynaptic density of neurons. DLGAP2 interacts with other synaptic proteins to scaffold and stabilize neurotransmitter receptors. Its expression is notable in regions like the cerebral cortex hippocampus and striatum emphasizing its importance in neurotransmission and synaptic plasticity.
Biological function summary

DLGAP2 functions are part of the synaptic signaling complex. It works closely with other proteins such as PSD-95 and SAPAP. These interactions help organize postsynaptic components essential for signal transduction and neuronal communication. By facilitating proper synapse organization DLGAP2 contributes to maintaining the efficiency of nerve signal transmission.

Pathways

DLGAP2 significantly influences synaptic signaling and plasticity. It integrates into pathways like the NMDA receptor signaling pathway interacting with proteins such as PSD-95 and SAP90. These connections allow DLGAP2 to regulate synaptic strength and plasticity which are fundamental for learning and memory processes.

Current research points to associations of DLGAP2 with autism spectrum disorders and schizophrenia. DLGAP2 abnormalities may affect synaptic organization and function contributing to the pathophysiology of these conditions. Through these pathways it interacts with proteins like Shank3 and neuroligins which are also implicated in neurodevelopmental and psychiatric disorders.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane.
See full target information DLGAP2
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Cell reports 41:111766 PubMed36476872

2022

Hippo-released WWC1 facilitates AMPA receptor regulatory complexes for hippocampal learning.

Applications

Unspecified application

Species

Unspecified reactive species

Jens Stepan,Daniel E Heinz,Frederik Dethloff,Thomas Bajaj,Andreas Zellner,Kathrin Hafner,Svenja Wiechmann,Sarah Mackert,Yara Mecdad,Michael Rabenstein,Tim Ebert,Silvia Martinelli,Alexander S Häusl,Maximilian L Pöhlmann,Anke Hermann,Xiao Ma,Hermann Pavenstädt,Mathias V Schmidt,Alexandra Philipsen,Chris W Turck,Jan M Deussing,Bernhard Kuster,Michael C Wehr,Valentin Stein,Joachim Kremerskothen,Carsten T Wotjak,Nils C Gassen

Brain : a journal of neurology 137:1481-95 PubMed24574503

2014

Ambroxol improves lysosomal biochemistry in glucocerebrosidase mutation-linked Parkinson disease cells.

Applications

Unspecified application

Species

Unspecified reactive species

Alisdair McNeill,Joana Magalhaes,Chengguo Shen,Kai-Yin Chau,Derralyn Hughes,Atul Mehta,Tom Foltynie,J Mark Cooper,Andrey Y Abramov,Matthew Gegg,Anthony H V Schapira
View all publications
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