Anti-DLX-3 antibody [Anti-Dlx3b]

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

DLX-3 also known as Distal-less homeobox 3 is a transcription factor with a molecular weight of approximately 32 kDa. It is a member of the homeobox gene family which plays roles in developmental processes. DLX-3 is mainly expressed in tissues like skin hair follicles and the placenta. It functions by binding to specific DNA sequences causing changes in gene expression during development.

Biological function summary

DLX-3 affects the development and differentiation processes in organisms. It interacts within a complex network of other homeobox genes influencing the development of craniofacial structures and skin. During early stages its role includes promoting cell differentiation necessary for forming specific tissues particularly in the ectoderm layer derivatives such as skin.

Pathways

Several genes contribute to the pathways involving DLX-3. DLX-3 participates in the Wnt signaling and BMP pathways acting as a regulator of gene transcription necessary for cellular differentiation. It interacts with other proteins like BMP2 showing functional overlap with other members of the DLX gene family. Through these interactions DLX-3 helps coordinate proper tissue development and maintenance.

Associated diseases and disorders

DLX-3 has associations with ectodermal dysplasias and certain craniofacial anomalies. It links to disorders like Tricho–Dento–Osseous (TDO) syndrome where mutations lead to defects in hair teeth and bone development. Apart from these DLX-3’s interactions with MSX1 highlight its role in dental and cranial disorders contributing to further understanding of hereditary conditions affecting developmental processes.