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AB234771

Anti-DMXL2 antibody

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(1 Publication)

Rabbit Polyclonal DMXL2 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human DMXL2 aa 2450-2700.

View Alternative Names

KIAA0856, DMXL2, DmX-like protein 2, Rabconnectin-3

2 Images
Immunocytochemistry/ Immunofluorescence - Anti-DMXL2 antibody (AB234771)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-DMXL2 antibody (AB234771)

HepG2 (human liver hepatocellular carcinoma cell line) cells stained for DMXL2 (green) using ab234771 at 1/100 dilution in ICC/IF, followed by an Alexa-Fluor® 488 conjugated Goat Anti-Rabbit IgG (H+L).

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DMXL2 antibody (AB234771)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DMXL2 antibody (AB234771)

Paraffin-embedded human brain tissue stained for DMXL2 using ab234771 at 1/100 dilution in immunohistochemical analysis.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human DMXL2 aa 2450-2700. The exact immunogen used to generate this antibody is proprietary information.

Q8TDJ6

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/50 - 1/200", "ICCIF-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Purity >95%
Storage buffer
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

DMXL2 also known as rabconnectin-3α is a large protein with a mass of approximately 350 kDa. It contains multiple WD40 repeats which suggests a role in protein-protein interactions. DMXL2 is expressed in various tissues with higher concentrations in the brain pituitary gland and reproductive organs. It functions mechanically in intracellular transport and signal transduction influencing neurotransmitter release and hormone secretion.
Biological function summary

DMXL2 plays a role in cellular homeostasis and communication. It is part of a protein complex associating with rab3 GTPase-activating proteins to regulate synaptic vesicle exocytosis. This protein contributes to the balance of Ca2+ dynamics in neuronal cells therefore influencing neurotransmitter release processes. Because it interacts directly with components involved in signaling DMXL2 impacts cellular responses to external stimuli.

Pathways

DMXL2 participates in the Notch signaling pathway and mTOR pathway. This protein interacts with key molecules such as rab3 a small GTPase essential for vesicle trafficking. The contribution of DMXL2 to these pathways enables it to orchestrate critical steps in cell growth proliferation and survival. By engaging in these pathways DMXL2 influences cellular metabolism and synaptic plasticity.

DMXL2 shows a connection to polycystic ovary syndrome (PCOS) and neurodegenerative disorders like Alzheimer's disease. Altered DMXL2 expression or function impacts reproductive endocrinology pathways related to PCOS where it can interact with proteins like FSH receptor. In Alzheimer's disease DMXL2's role in synaptic function ties it to amyloid-beta peptide processes an important aspect of the disease's progression. These connections highlight DMXL2 as a potential target for therapeutic intervention in these conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

May serve as a scaffold protein for MADD and RAB3GA on synaptic vesicles (PubMed : 11809763). Plays a role in the brain as a key controller of neuronal and endocrine homeostatic processes (By similarity).
See full target information DMXL2
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

The Journal of biological chemistry 294:9402-9415 PubMed31004036

2019

The priming factor CAPS1 regulates dense-core vesicle acidification by interacting with rabconnectin3β/WDR7 in neuroendocrine cells.

Applications

Unspecified application

Species

Unspecified reactive species

Ellen Crummy,Muralidharan Mani,John C Thellman,Thomas F J Martin
View all publications
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Product promise

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