Rabbit Polyclonal DMXL2 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human DMXL2 aa 1450-1500.
View Alternative Names
KIAA0856, DMXL2, DmX-like protein 2, Rabconnectin-3
- IP
Supplier Data
Immunoprecipitation - Anti-DMXL2 antibody (AB240690)
DMXL2 immunoprecipitated from Jurkat (human T cell leukemia cell line from peripheral blood) whole cell lysate (1.0 mg per IP reaction; 20% of IP loaded) prepared using NETN lysis buffer. Western blot was performed from the immunoprecipitate using ab240690 at 1/100 dilution.
Lane 1 : ab240690 used for IP at 20 μl per reaction in Jurkat whole cell lysate.
Lane 2 : Control IgG iP in Jurkat whole cell lysate.
Detection : Chemiluminescence with an exposure time of 30 seconds.
All lanes:
Immunoprecipitation - Anti-DMXL2 antibody (ab240690)
Predicted band size: 340 kDa
false
- WB
Supplier Data
Western blot - Anti-DMXL2 antibody (AB240690)
Lysates prepared using NETN lysis buffer.
All lanes:
Western blot - Anti-DMXL2 antibody (ab240690) at 1/1000 dilution
Lane 1:
HeLa (human epithelial cell line from cervix adenocarcinoma) whole cell lysate at 50 µg
Lane 2:
HEK-293T (human epithelial cell line from embryonic kidney transformed with large T antigen) whole cell lysate at 50 µg
Lane 3:
Jurkat (human T cell leukemia cell line from peripheral blood) whole cell lysate at 50 µg
Predicted band size: 340 kDa
true
Exposure time: 3min
Alternative Products
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Primary Antibodies
AB124673
Anti-Werner's syndrome helicase WRN antibody [EPR6392]
RabMAb|Recombinant|KO Validated|20ul selling size
![Western blot - Anti-Werner's syndrome helicase WRN antibody [EPR6392] (AB124673)](https://content.abcam.com/products/images/werners-syndrome-helicase-wrn-antibody-epr6392-ab124673--western-blot-img6988.jpg)
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- 1
Reactivity data
Properties and storage information
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Supplementary information
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Biological function summary
DMXL2 plays a role in cellular homeostasis and communication. It is part of a protein complex associating with rab3 GTPase-activating proteins to regulate synaptic vesicle exocytosis. This protein contributes to the balance of Ca2+ dynamics in neuronal cells therefore influencing neurotransmitter release processes. Because it interacts directly with components involved in signaling DMXL2 impacts cellular responses to external stimuli.
Pathways
DMXL2 participates in the Notch signaling pathway and mTOR pathway. This protein interacts with key molecules such as rab3 a small GTPase essential for vesicle trafficking. The contribution of DMXL2 to these pathways enables it to orchestrate critical steps in cell growth proliferation and survival. By engaging in these pathways DMXL2 influences cellular metabolism and synaptic plasticity.
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Target data
Publications (1)
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Stem cell research & therapy 16:324 PubMed40597299
2025
Applications
Unspecified application
Species
Unspecified reactive species
Product promise
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