AB122333

Anti-DNAH6 antibody

Name: Anti-DNAH6 antibody (ab122333) | Abcam
Brand: Abcam Limited
SKU: AB122333
Price: 630 USD
Availability: InStock

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(7 Publications)

Rabbit Polyclonal DNAH6 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 7 publications. Immunogen corresponding to Recombinant Fragment Protein within Human DNAH6 aa 1950 to C-terminus.

View Alternative Names

DNAHC6, DNHL1, HL2, KIAA1697, DNAH6, Dynein axonemal heavy chain 6, Axonemal beta dynein heavy chain 6, Ciliary dynein heavy chain 6

2 Images

Immunocytochemistry/ Immunofluorescence - Anti-DNAH6 antibody (AB122333)

ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-DNAH6 antibody (AB122333)

Immunofluorescent staining of Human cell line A-431 shows positivity in nucleus but not nucleoli, plasma membrane and cytoplasm. Recommended concentration of ab122333 1-4 µg/ml. Cells treated with PFA/Triton X-100.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DNAH6 antibody (AB122333)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DNAH6 antibody (AB122333)

ab122333, at a 1/850 dilution, staining DNAH6 in glandular cells of paraffin-embedded Human fallopian tube tissue by immunohistochemistry.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

ICC/IF, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human DNAH6 aa 1950 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q9C0G6

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/850", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1-4 µg/mL", "ICCIF-species-notes": "<p>Recommend PFA Fixation and Triton X-100 treatment</p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP (By similarity).

See full target information DNAH6

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Publications (7)

Recent publications for all applications. Explore the full list and refine your search

Human genomics 18:97 PubMed39256880

2024

Association of novel DNAH11 variants with asthenoteratozoospermia lead to male infertility.

Applications

Unspecified application

Species

Unspecified reactive species

Senzhao Guo,Dongdong Tang,Yuge Chen,Hui Yu,Meng Gu,Hao Geng,Jiajun Fang,Baoyan Wu,Lewen Ruan,Kuokuo Li,Chuan Xu,Yang Gao,Qing Tan,Zongliu Duan,Huan Wu,Rong Hua,Rui Guo,Zhaolian Wei,Ping Zhou,Yuping Xu,Yunxia Cao,Xiaojin He,Yanwei Sha,Mingrong Lv

Zoological research 45:1061-1072 PubMed39245650

2024

CCDC181 is required for sperm flagellum biogenesis and male fertility in mice.

Applications

Unspecified application

Species

Unspecified reactive species

Xiang-Jun Zhang,Xiao-Ning Hou,Jian-Teng Zhou,Bao-Lu Shi,Jing-Wei Ye,Meng-Lei Yang,Xiao-Hua Jiang,Bo Xu,Li-Min Wu,Qing-Hua Shi

Human reproduction open 2024:hoae003 PubMed38312775

2024

Bi-allelic variants in cause male infertility with asthenoteratozoospermia in humans and mice.

Applications

Unspecified application

Species

Unspecified reactive species

Gui-Quan Meng,Yaling Wang,Chen Luo,Yu-Mei Tan,Yong Li,Chen Tan,Chaofeng Tu,Qian-Jun Zhang,Liang Hu,Huan Zhang,Lan-Lan Meng,Chun-Yu Liu,Leiyu Deng,Guang-Xiu Lu,Ge Lin,Juan Du,Yue-Qiu Tan,Yanwei Sha,Lingbo Wang,Wen-Bin He

Asian journal of andrology 26:91-98 PubMed37594300

2023

Novel variants in DNAH6 cause male infertility associated with multiple morphological abnormalities of the sperm flagella (MMAF) and ICSI outcomes.

Applications

Unspecified application

Species

Unspecified reactive species

Zhong-Mei Shao,Yu-Tong Zhu,Meng Gu,Sen-Chao Guo,Hui Yu,Kuo-Kuo Li,Dong-Dong Tang,Yu-Ping Xu,Ming-Rong Lv

American journal of human genetics 108:1466-1477 PubMed34237282

2021

Bi-allelic mutations of DNAH10 cause primary male infertility with asthenoteratozoospermia in humans and mice.

Applications

Unspecified application

Species

Unspecified reactive species

Chaofeng Tu,Jiangshan Cong,Qianjun Zhang,Xiaojin He,Rui Zheng,Xiaoxuan Yang,Yang Gao,Huan Wu,Mingrong Lv,Yayun Gu,Shuai Lu,Chunyu Liu,Shixiong Tian,Lanlan Meng,Weili Wang,Chen Tan,Hongchuan Nie,Dongyan Li,Huan Zhang,Fei Gong,Liang Hu,Guangxiu Lu,Wenming Xu,Ge Lin,Feng Zhang,Yunxia Cao,Yue-Qiu Tan

Scientific reports 11:6939 PubMed33767253

2021

SPINK7 expression changes accompanied by HER2, P53 and RB1 can be relevant in predicting oral squamous cell carcinoma at a molecular level.

Applications

Unspecified application

Species

Unspecified reactive species

Gina Pennacchiotti,Fabio Valdés-Gutiérrez,Wilfredo Alejandro González-Arriagada,Héctor Federico Montes,Judith Maria Roxana Parra,Valeria Andrea Guida,Silvina Esther Gómez,Martin Eduardo Guerrero-Gimenez,Juan Manuel Fernandez-Muñoz,Felipe Carlos Martin Zoppino,Rubén Walter Carón,Marcelo Eduardo Ezquer,Ricardo Fernández-Ramires,Flavia Alejandra Bruna

Scientific reports 9:15864 PubMed31676830

2019

Identification of DNAH6 mutations in infertile men with multiple morphological abnormalities of the sperm flagella.

Applications

Unspecified application

Species

Unspecified reactive species

Chaofeng Tu,Hongchuan Nie,Lanlan Meng,Shimin Yuan,Wenbin He,Aixiang Luo,Haiyu Li,Wen Li,Juan Du,Guangxiu Lu,Ge Lin,Yue-Qiu Tan

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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Anti-DNAH6 antibody

Immunocytochemistry/ Immunofluorescence - Anti-DNAH6 antibody (AB122333)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DNAH6 antibody (AB122333)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Complementary Products

Secondary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Product protocols

Target data

Publications (7)

Product promise