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AB113241

Anti-DNase I antibody

5

(1 Review)

|

(5 Publications)

Rabbit Polyclonal DNase I antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human DNASE1.

View Alternative Names

DNL1, DRNI, DNASE1, Deoxyribonuclease-1, Deoxyribonuclease I, DNase I

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DNase I antibody (AB113241)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DNase I antibody (AB113241)

ab113241, at 10 µg/ml, staining DNase I in Formalin-fixed, Paraffin-embedded Human Brain cerebellum tissue by Immunohistochemistry.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DNase I antibody (AB113241)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DNase I antibody (AB113241)

ab113241, at 10 µg/ml, staining DNase I in Formalin-fixed, Paraffin-embedded Human Tonsil tissue by Immunohistochemistry.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Full Length Protein corresponding to Human DNASE1.

P24855

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "10 µg/mL", "IHCP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7 Preservative: 0.025% Proclin 300 Constituents: PBS, 20% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Serum endocuclease secreted into body fluids by a wide variety of exocrine and endocrine organs (PubMed : 11241278, PubMed : 2251263, PubMed : 2277032). Expressed by non-hematopoietic tissues and preferentially cleaves protein-free DNA (By similarity). Among other functions, seems to be involved in cell death by apoptosis (PubMed : 11241278). Binds specifically to G-actin and blocks actin polymerization (By similarity). Together with DNASE1L3, plays a key role in degrading neutrophil extracellular traps (NETs) (By similarity). NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation (By similarity). Degradation of intravascular NETs by DNASE1 and DNASE1L3 is required to prevent formation of clots that obstruct blood vessels and cause organ damage following inflammation (By similarity).
See full target information DNASE1
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Publications (5)

Recent publications for all applications. Explore the full list and refine your search

Pharmaceutics 16: PubMed39065664

2024

Development of a Clonal and High-Yield Mammalian Cell Line for the Manufacturing of a Hyperactive Human DNase I with Extended Plasma Half-Life Using PASylation Technology.

Applications

Unspecified application

Species

Unspecified reactive species

Serge M Stamm,Roland Wagner,Dietmar A Lang,Arne Skerra,Michaela Gebauer

PLoS genetics 18:e1010262 PubMed35793278

2022

Fragmentomics of urinary cell-free DNA in nuclease knockout mouse models.

Applications

Unspecified application

Species

Unspecified reactive species

Meihui Chen,Rebecca W Y Chan,Peter P H Cheung,Meng Ni,Danny K L Wong,Ze Zhou,Mary-Jane L Ma,Liangbo Huang,Xinzhou Xu,Wing-Shan Lee,Guangya Wang,Kathy O Lui,W K Jacky Lam,Jeremy Y C Teoh,Chi-Fai Ng,Peiyong Jiang,K C Allen Chan,Rossa W K Chiu,Y M Dennis Lo

The journal of pathology. Clinical research 4:193-203 PubMed29624903

2018

Lupus nephritis: low urinary DNase I levels reflect loss of renal DNase I and may be utilized as a biomarker of disease progression.

Applications

Unspecified application

Species

Unspecified reactive species

Hege L Pedersen,Kjersti D Horvei,Dhivya Thiyagarajan,Gudrun E Norby,Natalya Seredkina,Gabriella Moroni,Gro Ø Eilertsen,Hallvard Holdaas,Erik H Strøm,Gunnstein Bakland,Pier-Luigi Meroni,Ole P Rekvig

Frontiers in cell and developmental biology 6:7 PubMed29468159

2018

IL-1β Promotes a New Function of DNase I as a Transcription Factor for the Fas Receptor Gene.

Applications

Unspecified application

Species

Unspecified reactive species

Dhivya Thiyagarajan,Hege L Pedersen,Natalya Seredkina,Kjersti D Horvei,Lorena Arranz,Ramon Sonneveld,Tom Nijenhuis,Johan van der Vlag,Ole P Rekvig

The American journal of pathology 182:688-700 PubMed23273922

2013

Impact of the tumor necrosis factor receptor-associated protein 1 (Trap1) on renal DNaseI shutdown and on progression of murine and human lupus nephritis.

Applications

Unspecified application

Species

Unspecified reactive species

Silje Fismen,Dhivya Thiyagarajan,Natalya Seredkina,Henrik Nielsen,Søren Jacobsen,Thomas Elung-Jensen,Anne-Lise Kamper,Steinar D Johansen,Elin S Mortensen,Ole P Rekvig
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
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