Anti-DOK5 antibody [EPR9923(B)]

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

DOK5 also known as Docking Protein 5 is a member of the DOK family of intracellular adapter proteins. It has an approximate mass of 50 kDa. DOK5 primarily expresses in skeletal muscle and the nervous system including the brain and spinal cord. This protein facilitates signal transduction by acting as an adapter or scaffold for the assembly of signaling complexes integrating extracellular signals to downstream pathways.

Biological function summary

DOK5 plays a role in regulating cellular growth differentiation and apoptosis. It does not generally function as part of a larger complex but forms interactions that modulate signaling pathways. These functions depend on the ability of DOK5 to bind with key receptor tyrosine kinases including insulin and neurotrophin receptors. Its expression pattern and activities point to essential roles in muscle homeostasis and neuronal signaling.

Pathways

DOK5 is integral to the insulin signaling and neurotrophin signaling pathways. In relation to the insulin signaling pathway DOK5 interacts closely with insulin receptors and mediates downstream effects that influence glucose metabolism. The protein also forms part of the neurotrophin signaling pathway where it affects neuronal survival and differentiation in conjunction with associated proteins like TrkB and TrkC receptors.

Associated diseases and disorders

DOK5 associates with conditions such as insulin resistance and neurodevelopmental disorders. Alterations in DOK5 expression or function can contribute to aberrant insulin signaling potentially leading to type 2 diabetes. Additionally its role in the nervous system links DOK5 to neurodevelopmental disorders with connections to proteins such as TrkB which may further elucidate its involvement in neuronal defects.