Rabbit Polyclonal DOPA Decarboxylase/DDC antibody. N-terminal. Suitable for IHC-P, WB and reacts with Human, Cow samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human DDC conjugated to Keyhole Limpet Haemocyanin.
pH: 7.5
Constituents: 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, 0.24% HEPES, 0.01% BSA
IHC-P | WB | |
---|---|---|
Human | Tested | Tested |
Rat | Predicted | Predicted |
Cow | Expected | Tested |
Dog | Predicted | Predicted |
Guinea pig | Predicted | Predicted |
Sheep | Predicted | Predicted |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info 1/100 | Notes Perform heat-mediated antigen retrieval before commencing with IHC staining protocol. |
Species | Dilution info | Notes |
---|---|---|
Species Cow | Dilution info Use at an assay dependent concentration. | Notes - |
Species | Dilution info | Notes |
---|---|---|
Species Rat, Sheep, Guinea pig, Dog | Dilution info - | Notes - |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info 1/1000 | Notes - |
Species Cow | Dilution info 1/1000 | Notes - |
Species | Dilution info | Notes |
---|---|---|
Species Rat, Sheep, Guinea pig, Dog | Dilution info - | Notes - |
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Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine and L-5-hydroxytryptophan to serotonin.
AADC, DDC, Aromatic-L-amino-acid decarboxylase, DOPA decarboxylase
Rabbit Polyclonal DOPA Decarboxylase/DDC antibody. N-terminal. Suitable for IHC-P, WB and reacts with Human, Cow samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human DDC conjugated to Keyhole Limpet Haemocyanin.
pH: 7.5
Constituents: 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, 0.24% HEPES, 0.01% BSA
DOPA Decarboxylase also known as DDC or aromatic L-amino acid decarboxylase is an enzyme critical in neurotransmitter production. It has a molecular mass of approximately 54 kDa. DOPA Decarboxylase converts L-DOPA to dopamine and 5-HTP to serotonin. This enzyme is expressed in tissues like the brain liver and kidney with high activity levels in the central nervous system.
DOPA Decarboxylase plays an essential role in the synthesis of neurotransmitters such as dopamine and serotonin. It functions as part of the enzymatic conversion process and is not typically associated with larger complexes. The availability and activity of DDC directly influence the levels of these neurotransmitters affecting various physiological responses.
DOPA Decarboxylase participates in the catecholamine biosynthesis pathway. This pathway is important for regulating body functions like mood motivation and fine motor control. DDC activity connects it with proteins such as tyrosine hydroxylase which provides the precursor L-DOPA for dopamine synthesis. Additionally it is involved in the serotonin biosynthesis pathway alongside tryptophan hydroxylase.
DOPA Decarboxylase shows significant relevance to conditions like Parkinson's disease and depression. Reduced DDC activity results in decreased dopamine levels which contribute to Parkinson’s symptoms. In depression altered DDC function affects serotonin levels. Its interaction with proteins like monoamine oxidase also plays a role in these disorders due to their involvement in neurotransmitter metabolism.
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Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human kidney tissue labeling DOPA Decarboxylase/DDC with ab189101 at 1/100.
All lanes: Western blot - Anti-DOPA Decarboxylase/DDC antibody - N-terminal (ab189101) at 1/1000 dilution
All lanes: Human caudate lysate at 20 µg
Predicted band size: 53 kDa
All lanes: Western blot - Anti-DOPA Decarboxylase/DDC antibody - N-terminal (ab189101) at 1/1000 dilution
All lanes: Bovine adrenal medulla lysate at 5 µg
Predicted band size: 53 kDa
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