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Rabbit Polyclonal DOPA Decarboxylase/DDC antibody. N-terminal. Suitable for IHC-P, WB and reacts with Human, Cow samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human DDC conjugated to Keyhole Limpet Haemocyanin.

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Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DOPA Decarboxylase/DDC antibody - N-terminal (AB189101), expandable thumbnail
  • Western blot - Anti-DOPA Decarboxylase/DDC antibody - N-terminal (AB189101), expandable thumbnail
  • Western blot - Anti-DOPA Decarboxylase/DDC antibody - N-terminal (AB189101), expandable thumbnail

Publications

Key facts

Isotype
IgG
Host species
Rabbit
Storage buffer

pH: 7.5
Constituents: 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, 0.24% HEPES, 0.01% BSA

Form
Liquid
Clonality
Polyclonal

Immunogen

  • Synthetic Peptide within Human DDC conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information. Database link P20711

Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
IHC-PWB
Human
Tested
Tested
Rat
Predicted
Predicted
Cow
Expected
Tested
Dog
Predicted
Predicted
Guinea pig
Predicted
Predicted
Sheep
Predicted
Predicted

Tested
Tested

Species
Human
Dilution info
1/100
Notes

Perform heat-mediated antigen retrieval before commencing with IHC staining protocol.

Expected
Expected

Species
Cow
Dilution info
Use at an assay dependent concentration.
Notes

-

Predicted
Predicted

Species
Rat, Sheep, Guinea pig, Dog
Dilution info
-
Notes

-

Tested
Tested

Species
Human
Dilution info
1/1000
Notes

-

Species
Cow
Dilution info
1/1000
Notes

-

Predicted
Predicted

Species
Rat, Sheep, Guinea pig, Dog
Dilution info
-
Notes

-

Associated Products

Select an associated product type

2 products for Alternative Product

Target data

Function

Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine and L-5-hydroxytryptophan to serotonin.

Alternative names

Recommended products

Rabbit Polyclonal DOPA Decarboxylase/DDC antibody. N-terminal. Suitable for IHC-P, WB and reacts with Human, Cow samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human DDC conjugated to Keyhole Limpet Haemocyanin.

Key facts

Isotype
IgG
Form
Liquid
Clonality
Polyclonal
Immunogen
  • Synthetic Peptide within Human DDC conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information. Database link P20711
Purification technique
Affinity purification Immunogen
Concentration
Loading...

Storage

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.
Activity summary

DOPA Decarboxylase also known as DDC or aromatic L-amino acid decarboxylase is an enzyme critical in neurotransmitter production. It has a molecular mass of approximately 54 kDa. DOPA Decarboxylase converts L-DOPA to dopamine and 5-HTP to serotonin. This enzyme is expressed in tissues like the brain liver and kidney with high activity levels in the central nervous system.

Biological function summary

DOPA Decarboxylase plays an essential role in the synthesis of neurotransmitters such as dopamine and serotonin. It functions as part of the enzymatic conversion process and is not typically associated with larger complexes. The availability and activity of DDC directly influence the levels of these neurotransmitters affecting various physiological responses.

Pathways

DOPA Decarboxylase participates in the catecholamine biosynthesis pathway. This pathway is important for regulating body functions like mood motivation and fine motor control. DDC activity connects it with proteins such as tyrosine hydroxylase which provides the precursor L-DOPA for dopamine synthesis. Additionally it is involved in the serotonin biosynthesis pathway alongside tryptophan hydroxylase.

Associated diseases and disorders

DOPA Decarboxylase shows significant relevance to conditions like Parkinson's disease and depression. Reduced DDC activity results in decreased dopamine levels which contribute to Parkinson’s symptoms. In depression altered DDC function affects serotonin levels. Its interaction with proteins like monoamine oxidase also plays a role in these disorders due to their involvement in neurotransmitter metabolism.

Product promise

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In the unlikely event of one of our products not working as expected, you are covered by our product promise.

Full details and terms and conditions can be found here:
Terms & Conditions.

3 product images

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DOPA Decarboxylase/DDC antibody - N-terminal (ab189101), expandable thumbnail

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DOPA Decarboxylase/DDC antibody - N-terminal (ab189101)

    Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human kidney tissue labeling DOPA Decarboxylase/DDC with ab189101 at 1/100.

  • Western blot - Anti-DOPA Decarboxylase/DDC antibody - N-terminal (ab189101), expandable thumbnail

    Western blot - Anti-DOPA Decarboxylase/DDC antibody - N-terminal (ab189101)

    All lanes: Western blot - Anti-DOPA Decarboxylase/DDC antibody - N-terminal (ab189101) at 1/1000 dilution

    All lanes: Human caudate lysate at 20 µg

    Predicted band size: 53 kDa

  • Western blot - Anti-DOPA Decarboxylase/DDC antibody - N-terminal (ab189101), expandable thumbnail

    Western blot - Anti-DOPA Decarboxylase/DDC antibody - N-terminal (ab189101)

    All lanes: Western blot - Anti-DOPA Decarboxylase/DDC antibody - N-terminal (ab189101) at 1/1000 dilution

    All lanes: Bovine adrenal medulla lysate at 5 µg

    Predicted band size: 53 kDa

Downloads

Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

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