AB20066

Anti-Dopamine Receptor D1 antibody

Name: Anti-Dopamine Receptor D1 antibody. Rabbit polyclonal (ab20066) | Abcam
Brand: Abcam Limited
SKU: AB20066
Price: 595 USD
Availability: InStock
Rating: 4 (11 reviews)

(11 Reviews)

(63 Publications)

Rabbit Polyclonal Dopamine Receptor D1 antibody. Suitable for WB and reacts with Rat, Human samples. Cited in 63 publications. Immunogen corresponding to Synthetic Peptide within Human DRD1 aa 1-50.

View Alternative Names

D(1A) dopamine receptor, Dopamine D1 receptor, DRD1

1 Images

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Western blot - Anti-Dopamine Receptor D1 antibody (AB20066)

All lanes:

Western blot - Anti-Dopamine Receptor D1 antibody (ab20066) at 1 µg/mL

Lane 1:

Human brain tissue lysate - total protein (<a href='/en-us/products/unavailable/human-brain-tissue-lysate-total-protein-ab29466'>ab29466</a>) at 10 µg

Lane 2:

Rat Forebrain at 10 µg

Lane 3:

Rat Cortex Tissue Lysate at 10 µg

Secondary

All lanes:

Goat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilution

Predicted band size: 49 kDa

Observed band size: 45 kDa,48 kDa,70 kDa,75 kDa

true

Exposure time: 90s

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Rat, Human

Applications

applications

Immunogen

Synthetic Peptide within Human DRD1 aa 1-50. The exact immunogen used to generate this antibody is proprietary information.

P21728

Specificity

Stains specific cells in various regions of PLP fixed Rat brain sections. This includes Medial septum, Nucleus accumbens, Dentate gyrus, Globus pallidus, Medial forebrain bundle, Cortex regions 1-3, Substantia Nigra reticulata, and the Ventral tegmental area. Cross reactivity: D1 Dopamine Receptor (9-21) 100%; D1 Dopamine Receptor 90%; D2 Dopamine Receptor (272-282) 0%; D2 Dopamine Receptor 0%; D3 Dopamine Receptor (2-10) 0%; D3 Dopamine Receptor 0; D4 Dopamine Receptor (176-185) 0%; D4 Dopamine Receptor 0%; D5 Dopamine Receptor (23-35) 0%; D5 Dopamine Receptor 0%

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000", "WB-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000", "WB-species-notes": "<p></p>" } } }

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Properties and storage information

Form

Liquid

Purity

Whole antiserum

Storage buffer

Constituents: PBS, 1% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Storage information

Avoid freeze / thaw cycle

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. Forms heterotetramers with DRD3 to potentiate beta-arrestin recruitment and mediate locomotor activity.

See full target information DRD1

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Publications (63)

Recent publications for all applications. Explore the full list and refine your search

NPJ Parkinson's disease 11:175 PubMed40537481

2025

Butyrate improves abnormal sleep architecture in a Parkinson's disease mouse model via BDNF/TrkB signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Wen-Xiang Duan,Wei-Ye Xie,Chen Ying,Wang Fen,Xiao-Yu Cheng,Cheng-Jie Mao,Jun-Yi Liu,Chun-Feng Liu

Journal of neurophysiology 133:374-387 PubMed39706150

2024

Dopamine receptors D1, D2, and D4 modulate electrical synapses and excitability in the thalamic reticular nucleus.

Applications

Unspecified application

Species

Unspecified reactive species

Mitchell J Vaughn,Nandini Yellamelli,R Michael Burger,Julie S Haas

Journal of extracellular vesicles 13:e70018 PubMed39641313

2024

Dopamine-conjugated extracellular vesicles induce autophagy in Parkinson's disease.

Applications

Unspecified application

Species

Unspecified reactive species

Jae Hoon Sul,Sol Shin,Hark Kyun Kim,Jihoon Han,Junsik Kim,Soyong Son,Jungmi Lee,Seung Hyun Baek,Yoonsuk Cho,Jeongmi Lee,Jinsu Park,Donghoon Ahn,Sunyoung Park,Leon F Palomera,Jeein Lim,Jongho Kim,Chanhee Kim,Seungsu Han,Ka Young Chung,Sangho Lee,Tae-In Kam,Yunjong Lee,Jeongyun Kim,Jae Hyung Park,Dong-Gyu Jo

Advanced science (Weinheim, Baden-Wurttemberg, Germany) 11:e2401855 PubMed38973158

2024

Distinct Thalamo-Subcortical Circuits Underlie Painful Behavior and Depression-Like Behavior Following Nerve Injury.

Applications

Unspecified application

Species

Unspecified reactive species

Jie Deng,Li Chen,Cui-Cui Liu,Meng Liu,Guo-Qing Guo,Jia-You Wei,Jian-Bo Zhang,Hai-Ting Fan,Zi-Kun Zheng,Pu Yan,Xiang-Zhong Zhang,Feng Zhou,Sui-Xiang Huang,Ji-Feng Zhang,Ting Xu,Jing-Dun Xie,Wen-Jun Xin

Journal of Cancer 15:1041-1052 PubMed38230224

2024

Blockade of spinal dopamine D1/D2 receptor heteromers by -Corydalmine suppressed calcium signaling cascade in spinal neurons to alleviate bone cancer pain in rats.

Applications

Unspecified application

Species

Unspecified reactive species

Xiao-Nan Ma,Chang-Heng Yao,Yu-Jie Yang,Xue Li,Meng-Yuan Zhou,Jin Yang,Shen Zhang,Bo-Yang Yu,Wen-Ling Dai,Ji-Hua Liu

Biomedicines 11: PubMed37239153

2023

Brain-Derived Neurotrophic Factor (BDNF) in Mechanisms of Autistic-like Behavior in BTBR Mice: Crosstalk with the Dopaminergic Brain System.

Applications

Unspecified application

Species

Unspecified reactive species

Tatiana Ilchibaeva,Anton Tsybko,Marina Lipnitskaya,Dmitry Eremin,Kseniya Milutinovich,Vladimir Naumenko,Nina Popova

Fluids and barriers of the CNS 19:95 PubMed36437472

2022

Modulation of striatal glutamatergic, dopaminergic and cholinergic neurotransmission pathways concomitant with motor disturbance in rats with kaolin-induced hydrocephalus.

Applications

Unspecified application

Species

Unspecified reactive species

Li-Jin Chen,Jeng-Rung Chen,Guo-Fang Tseng

Evidence-based complementary and alternative medicine : eCAM 2022:9139841 PubMed36337583

2022

"Jing-Ning Granules" Can Alleviate Attention Deficit Hyperactivity Disorder in Rats by Modulating Dopaminergic D2/D1-Like Receptor-Mediated Signaling Pathways.

Applications

Unspecified application

Species

Unspecified reactive species

Jie Ding,Yiyun Ding,Jingjing Wu,Jialin Deng,Qingyang Yu,Junhong Wang

Journal of neurochemistry 162:166-189 PubMed35621027

2022

Up-regulation of cell division cycle 20 expression alters the morphology of neuronal dendritic spines in the nucleus accumbens by promoting FMRP ubiquitination.

Applications

Unspecified application

Species

Unspecified reactive species

Xin Wang,Fei Li,Jun Zhu,Dayun Feng,Yingwu Shi,Liang Qu,Yang Li,Kang Guo,Yue Zhang,Qiang Wang,Naigeng Wang,Xuelian Wang,Shunnan Ge

Frontiers in cellular neuroscience 16:893190 PubMed35711471

2022

Knockout of Dopamine D3 Receptor Gene Blocked Methamphetamine-Induced Distinct Changes of Dopaminergic and Glutamatergic Synapse in the Nucleus Accumbens Shell of Mice.

Applications

Unspecified application

Species

Unspecified reactive species

Shuai Wang,Ming Li,Linlan Su,Yu Wang,Dongliang Ma,Hongyan Wang,Jie Zhu,Teng Chen

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Dopamine Receptor D1 antibody

Western blot - Anti-Dopamine Receptor D1 antibody (AB20066)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Specificity

Complementary Products

Primary Antibodies

Secondary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity data

Properties and storage information

Form

Purity

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Storage information

Product protocols

Target data

Publications (63)

Product promise