AB153668

Anti-Doublecortin antibody

Name: Anti-Doublecortin antibody. Chicken polyclonal (ab153668) | Abcam
Brand: Abcam Limited
SKU: AB153668
Price: 515 USD
Availability: InStock
Rating: 5 (3 reviews)

(3 Reviews)

(23 Publications)

Chicken Polyclonal Doublecortin antibody. Suitable for IHC-P, ICC/IF and reacts with Mouse samples. Cited in 23 publications. Immunogen corresponding to Synthetic Peptide within Human DCX conjugated to Keyhole Limpet Haemocyanin.

View Alternative Names

DBCN, LISX, DCX, Neuronal migration protein doublecortin, Doublin, Lissencephalin-X, Lis-X

3 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Doublecortin antibody (AB153668)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Doublecortin antibody (AB153668)

Immunohistochemistry (4% PFA-fixed, paraffin-embedded) analysis of e18 mouse cochlear ganglion tissue labelling Doublecortin (green) with ab153668. Tissue was fixed with 4% paraformaldehyde. Red - rabbit anti-Beta-Tubulin 3.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Doublecortin antibody (AB153668)

Immunohistochemistry (4% PFA-fixed, paraffin-embedded section) analysis of e18 mouse brain (periventricular zone) tissue labelling Doublecortin (red) with ab153668. Green - GFP autofluorescence.

Immunocytochemistry/ Immunofluorescence - Anti-Doublecortin antibody (AB153668)

ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-Doublecortin antibody (AB153668)

Immunocytochemistry/Immunofluorescence analysis of SpH64 cells in culture labelling Doublecortin (green) with ab153668. Cells were fixed with 4% paraformaldehyde. Red - rabbit anti-Golgi Marker.

Key facts

Host species

Chicken

Clonality

Polyclonal

Isotype

IgY

Carrier free

Reacts with

Mouse

Applications

IHC-P, ICC/IF

applications

Immunogen

Synthetic Peptide within Human DCX conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

O43602

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/1000", "IHCP-species-notes": "<p>4% PFA-fixed, paraffin-embedded section.</p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "<p>Use 2% paraformaldehyde-fixed cells.</p>" } } }

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Product details

Do not freeze this antibody unless you want to store them for longer periods of time.

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7 Preservative: 0.02% Sodium azide Constituents: PBS

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

+4°C

Storage information

Store in the dark

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Microtubule-associated protein required for initial steps of neuronal dispersion and cortex lamination during cerebral cortex development. May act by competing with the putative neuronal protein kinase DCLK1 in binding to a target protein. May in that way participate in a signaling pathway that is crucial for neuronal interaction before and during migration, possibly as part of a calcium ion-dependent signal transduction pathway. May be part with PAFAH1B1/LIS-1 of overlapping, but distinct, signaling pathways that promote neuronal migration.

See full target information DCX

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Publications (23)

Recent publications for all applications. Explore the full list and refine your search

Cell death discovery 11:194 PubMed40268899

2025

Pkd2l1 deletion inhibits the neurogenesis of cerebrospinal fluid-contacting neurons and impedes spinal cord injury repair.

Applications

Unspecified application

Species

Unspecified reactive species

Yi Zhang,Liang Cao,Haijian Yan,Zhangrong Luo,Chanjuan Chen,Zeyu Shangguan,Qizhe Li,Xuexing Shi,Leiluo Yang,Wei Tan,Shengxin Yang,Jiangquan Fu,Chunqing Wang,Xiaowei Dou,Qing Li

Regenerative biomaterials 11:rbae111 PubMed39323747

2024

Cross-linking manipulation of waterborne biodegradable polyurethane for constructing mechanically adaptable tissue engineering scaffolds.

Applications

Unspecified application

Species

Unspecified reactive species

Nan Sheng,Weiwei Lin,Jingjing Lin,Yuan Feng,Yanchao Wang,Xueling He,Yuanyuan He,Ruichao Liang,Zhen Li,Jiehua Li,Feng Luo,Hong Tan

Pediatric research 97:1199-1208 PubMed39085403

2024

Neuroserpin normalization by mesenchymal stem cell therapy after encephalopathy of prematurity in neonatal rats.

Applications

Unspecified application

Species

Unspecified reactive species

Lan-Wan Wang,Chien-Wei Hsiung,Ching-Ping Chang,Mao-Tsun Lin,Shyi-Jou Chen

Cell reports 42:112845 PubMed37480564

2023

PCDH12 loss results in premature neuronal differentiation and impeded migration in a cortical organoid model.

Applications

Unspecified application

Species

Unspecified reactive species

Jennifer Rakotomamonjy,Lauren Rylaarsdam,Lucas Fares-Taie,Sean McDermott,Devin Davies,George Yang,Fikayo Fagbemi,Maya Epstein,Martín Fairbanks-Santana,Jean-Michel Rozet,Alicia Guemez-Gamboa

Molecular psychiatry 28:3002-3012 PubMed37131071

2023

Gut microbiota changes require vagus nerve integrity to promote depressive-like behaviors in mice.

Applications

Unspecified application

Species

Unspecified reactive species

Eleni Siopi,Mathieu Galerne,Manon Rivagorda,Soham Saha,Carine Moigneu,Stéphanie Moriceau,Mathilde Bigot,Franck Oury,Pierre-Marie Lledo

Nature aging 3:213-228 PubMed37118117

2023

Systemic GDF11 attenuates depression-like phenotype in aged mice via stimulation of neuronal autophagy.

Applications

Unspecified application

Species

Unspecified reactive species

Carine Moigneu,Soumia Abdellaoui,Mariana Ramos-Brossier,Bianca Pfaffenseller,Bianca Wollenhaupt-Aguiar,Taiane de Azevedo Cardoso,Claire Camus,Aurélie Chiche,Nicolas Kuperwasser,Ricardo Azevedo da Silva,Fernanda Pedrotti Moreira,Han Li,Franck Oury,Flávio Kapczinski,Pierre-Marie Lledo,Lida Katsimpardi

Nature communications 14:373 PubMed36690670

2023

Post-transcriptional control of a stemness signature by RNA-binding protein MEX3A regulates murine adult neurogenesis.

Applications

Unspecified application

Species

Unspecified reactive species

Ana Domingo-Muelas,Pere Duart-Abadia,Jose Manuel Morante-Redolat,Antonio Jordán-Pla,Germán Belenguer,Jaime Fabra-Beser,Lucía Paniagua-Herranz,Ana Pérez-Villalba,Adrián Álvarez-Varela,Francisco M Barriga,Cristina Gil-Sanz,Felipe Ortega,Eduard Batlle,Isabel Fariñas

Cellular and molecular life sciences : CMLS 80:36 PubMed36627412

2023

The rates of adult neurogenesis and oligodendrogenesis are linked to cell cycle regulation through p27-dependent gene repression of SOX2.

Applications

Unspecified application

Species

Unspecified reactive species

Ana Domingo-Muelas,Jose Manuel Morante-Redolat,Verónica Moncho-Amor,Antonio Jordán-Pla,Ana Pérez-Villalba,Pau Carrillo-Barberà,Germán Belenguer,Eva Porlan,Martina Kirstein,Oriol Bachs,Sacri R Ferrón,Robin Lovell-Badge,Isabel Fariñas

Cerebral cortex (New York, N.Y. : 1991) 33:5906-5923 PubMed36573432

2022

Expression patterns of NKCC1 in neurons and non-neuronal cells during cortico-hippocampal development.

Applications

Unspecified application

Species

Unspecified reactive species

Samu N Kurki,Pavel Uvarov,Alexey S Pospelov,Kalevi Trontti,Antje K Hübner,Rakenduvadhana Srinivasan,Masahiko Watanabe,Iiris Hovatta,Christian A Hübner,Kai Kaila,Mari A Virtanen

The EMBO journal 41:e110595 PubMed36305367

2022

BCL7A-containing SWI/SNF/BAF complexes modulate mitochondrial bioenergetics during neural progenitor differentiation.

Applications

Unspecified application

Species

Unspecified reactive species

Lena Wischhof,Hang-Mao Lee,Janine Tutas,Clemens Overkott,Eileen Tedt,Miriam Stork,Michael Peitz,Oliver Brüstle,Thomas Ulas,Kristian Händler,Joachim L Schultze,Dan Ehninger,Pierluigi Nicotera,Paolo Salomoni,Daniele Bano

View all publications

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