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AB186831

Anti-DP1 antibody

2

(3 Reviews)

|

(2 Publications)

Rabbit Polyclonal DP1 antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human TFDP1 aa 1-300.

View Alternative Names

DP1, TFDP1, Transcription factor Dp-1, DRTF1-polypeptide 1, E2F dimerization partner 1, DRTF1

3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DP1 antibody (AB186831)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DP1 antibody (AB186831)

Paraffin-embedded human lung tissue stained for DP1 using ab186831 at 1/200 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DP1 antibody (AB186831)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DP1 antibody (AB186831)

Paraffin-embedded human colon damage stained for DP1 using ab186831 at 1/200 dilution in immunohistochemical analysis.

Western blot - Anti-DP1 antibody (AB186831)
  • WB

Supplier Data

Western blot - Anti-DP1 antibody (AB186831)

Blocking buffer : 3% nonfat dry milk in TBST.

All lanes:

Western blot - Anti-DP1 antibody (ab186831) at 1/3000 dilution

Lane 1:

LO2 cell lysate at 25 µg

Lane 2:

Raji cell lysate at 25 µg

Lane 3:

Mouse kidney tissue lysate at 25 µg

Secondary

All lanes:

HRP Goat Anti-Rabbit IgG (H+L)

Predicted band size: 45 kDa

true

Exposure time: 90s

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human TFDP1 aa 1-300. The exact immunogen used to generate this antibody is proprietary information.

Q14186

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.3 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The DP1 receptor also known as the prostaglandin D2 receptor 1 is a G-protein-coupled receptor with a molecular mass of approximately 44 kDa. This receptor binds to prostaglandin D2 (PGD2) and is found in various tissues including the central nervous system lungs and some immune cells. The presence of DP1 in these tissues suggests a role in multiple physiological processes reflecting its distribution in the body.
Biological function summary

Prostaglandin D2 (PGD2) plays a significant role in mediating inflammatory and allergic responses. The DP1 receptor is part of a signaling complex that modulates smooth muscle relaxation inhibition of platelet aggregation and sleep induction. Its expression in both neural and peripheral tissues underlines its involvement in a range of biological functions including the regulation of sleep-wake cycles and inflammation.

Pathways

The DP1 receptor contributes significantly to the prostaglandin signaling pathway which involves other prostaglandin receptors such as DP2 and EP receptors. This pathway mediates various physiological responses including vasodilation and immune modulation. The signaling interactions between DP1 and these related receptors help coordinate complex biological processes such as the regulation of vascular tone and inflammatory responses.

Abnormal DP1 signaling relates to asthma and allergic rhinitis conditions where inflammation and immune response are dysregulated. Overactivation or altered regulation of DP1 can exacerbate these diseases often involving other proteins like COX-2 which elevate levels of PGD2 during inflammation. Understanding DP1's role offers potential therapeutic angles for managing allergic and inflammatory diseases.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication (PubMed : 7739537, PubMed : 8405995). The E2F1 : DP complex appears to mediate both cell proliferation and apoptosis. Blocks adipocyte differentiation by repressing CEBPA binding to its target gene promoters (PubMed : 20176812).
See full target information TFDP1
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Chemistry & biodiversity 22:e202402771 PubMed39776239

2025

Protocatechuic Acid Improves Alzheimer's Disease by Regulating the Cholinergic Synaptic Signaling Pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Siwen Li,Songtao Li,Rasmané Semde,Hongbo Teng,Mengqi Shi,Liang Huang,Xinru Lou,Beining Jia,Hongyan Zhu,Yan Zhao

Cancer biology & medicine 20: PubMed37283490

2023

Identification of the E2F1-RAD51AP1 axis as a key factor in MGMT-methylated GBM TMZ resistance.

Applications

Unspecified application

Species

Unspecified reactive species

Junhu Zhou,Fei Tong,Jixing Zhao,Xiaoteng Cui,Yunfei Wang,Guangxiu Wang,Chunsheng Kang,Xiaomin Liu,Qixue Wang
View all publications
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Product promise

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For full details, please see our Terms & Conditions

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