Anti-DPP10 antibody - Extracellular domain

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

DPP10 short for Dipeptidyl Peptidase-Like Protein 10 is a single-pass type II membrane protein with a molecular mass of approximately 90 kDa. This protein does not have enzymatic activity like other members of the DPP family but it still plays a significant mechanical role in the modulation of voltage-gated potassium channels. DPP10 is widely expressed in human tissues with notable expression in the brain and pancreas. Its function involves participating in the regulation of electrical signaling in neurons.

Biological function summary

The target acts as an important auxiliary subunit for the Kv4 family of potassium channels forming a complex that affects channel gating and kinetics. This interaction modulates the function of these channels and contributes to the shaping of action potentials and neuronal excitability. As a part of this complex DPP10 is necessary for modulating the opening and closing speed of the channels affecting how signals propagate through neurons.

Pathways

DPP10 significantly influences the cardiac and neuronal action potential pathways. By modulating the Kv4 channels it indirectly contributes to the integrity of electrical signaling in both heart and brain. These channels are important components of the transient outward potassium current intimately related to proteins such as Kv4.2 and Kv4.3. This connection positions DPP10 as an elemental regulator within these key physiological processes.

Associated diseases and disorders

Researchers have linked aberrant expression or function of DPP10 to neurological conditions like epilepsy and asthma. Its involvement in epilepsy connects to the modulation of neuronal excitability potentially through interactions with other proteins like Kv4.2. In asthma alterations in DPP10 expression may affect respiratory function although the exact mechanisms remain a research interest. Understanding these connections can contribute to developing therapeutic strategies targeting these conditions.