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AB188820

Anti-DPP10 antibody - Extracellular domain

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(1 Publication)

Rabbit Polyclonal DPP10 antibody. Extracellular domain. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human DPP10.

View Alternative Names

DPRP3, KIAA1492, DPP10, Inactive dipeptidyl peptidase 10, Dipeptidyl peptidase IV-related protein 3, Dipeptidyl peptidase X, Dipeptidyl peptidase-like protein 2, DPRP-3, DPP X, DPL2

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DPP10 antibody - Extracellular domain (AB188820)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DPP10 antibody - Extracellular domain (AB188820)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human brain tissue, labeling DPP10 using ab188820 at 10 μg/ml.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human DPP10. The exact immunogen used to generate this antibody is proprietary information.

Q8N608

Specificity

BLAST analysis of the peptide immunogen showed no homology with other Human proteins.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "10 µg/mL", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval before commencing with IHC staining protocol." }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Cow": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Dog": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Gorilla": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Horse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Monkey": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Pig": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rabbit": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.1% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

DPP10 short for Dipeptidyl Peptidase-Like Protein 10 is a single-pass type II membrane protein with a molecular mass of approximately 90 kDa. This protein does not have enzymatic activity like other members of the DPP family but it still plays a significant mechanical role in the modulation of voltage-gated potassium channels. DPP10 is widely expressed in human tissues with notable expression in the brain and pancreas. Its function involves participating in the regulation of electrical signaling in neurons.
Biological function summary

The target acts as an important auxiliary subunit for the Kv4 family of potassium channels forming a complex that affects channel gating and kinetics. This interaction modulates the function of these channels and contributes to the shaping of action potentials and neuronal excitability. As a part of this complex DPP10 is necessary for modulating the opening and closing speed of the channels affecting how signals propagate through neurons.

Pathways

DPP10 significantly influences the cardiac and neuronal action potential pathways. By modulating the Kv4 channels it indirectly contributes to the integrity of electrical signaling in both heart and brain. These channels are important components of the transient outward potassium current intimately related to proteins such as Kv4.2 and Kv4.3. This connection positions DPP10 as an elemental regulator within these key physiological processes.

Researchers have linked aberrant expression or function of DPP10 to neurological conditions like epilepsy and asthma. Its involvement in epilepsy connects to the modulation of neuronal excitability potentially through interactions with other proteins like Kv4.2. In asthma alterations in DPP10 expression may affect respiratory function although the exact mechanisms remain a research interest. Understanding these connections can contribute to developing therapeutic strategies targeting these conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Promotes cell surface expression of the potassium channel KCND2 (PubMed : 15454437). Modulates the activity and gating characteristics of the potassium channel KCND2 (PubMed : 15454437). Has no dipeptidyl aminopeptidase activity (PubMed : 12662155).
See full target information DPP10
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Scientific reports 14:14185 PubMed38902391

2024

A prominent role of LncRNA H19 in H. pylori CagA induced DNA damage response and cell malignancy.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaofeng He,Tingting Huang,Qinrong Wang,Liya Bao,Zhengrong Wang,Hui Song,Yanhong Li,Jianjiang Zhou,Yan Zhao,Yuan Xie
View all publications
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