AB42075

Anti-DPP8 antibody - Aminoterminal end

Name: Anti-DPP8 antibody - Aminoterminal end (ab42075) | Abcam
Brand: Abcam Limited
SKU: AB42075
Rating: 4 (2 reviews)

(2 Reviews)

(3 Publications)

Rabbit Polyclonal DPP8 antibody. Suitable for WB and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human DPP8.

View Alternative Names

DPRP1, MSTP097, MSTP135, MSTP141, DPP8, Dipeptidyl peptidase 8, DP8, Dipeptidyl peptidase IV-related protein 1, Dipeptidyl peptidase VIII, Prolyl dipeptidase DPP8, DPRP-1, DPP VIII

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

applications

Immunogen

Synthetic Peptide within Human DPP8. The exact immunogen used to generate this antibody is proprietary information.

Q6V1X1

Specificity

This antibody recognizes all four forms of DPP8. This antibody does not recognize other DPP family members.

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Reactivity data

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Product details

This antibody recognizes all four forms of DPP8

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

Preservative: 0.05% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 2.9% Sodium chloride

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Dipeptidyl peptidase 8 also known as DPP8 is a serine protease enzyme that cleaves x-proline dipeptides from the N-termini of peptides. It has a molecular mass of around 88 kDa and shares structural similarities with DPP4. DPP8 is expressed in various tissues including the brain liver and skin but shows a notably high expression in immune cells. The enzyme is involved in regulating various physiological processes depending on its tissue distribution.

Biological function summary

DPP8 seems to play roles in modulating immune responses and cell proliferation. It functions independently and is not typically part of a larger protein complex. Studies suggest a connection between DPP8 and cellular processes such as apoptosis and inflammation although the exact biological roles require more detailed investigation.

Pathways

The peptidase activity of DPP8 integrates within metabolic and immune system pathways. In the context of metabolism it relates closely to proteins like DPP4 which influences glucose homeostasis. In immune pathways DPP8 regulates the processing of peptides affecting immune cell communication and activity sharing roles with other immune-related proteases.

DPP8 exhibits connections with inflammatory and metabolic conditions. For example its dysregulation may relate to inflammatory bowel disease (IBD) possibly affecting inflammatory cytokine release. DPP8's function parallels with DPP4 linking it indirectly to disorders like type 2 diabetes where DPP4 inhibitors are a therapeutic angle. Further exploration of DPP8's roles could indicate potential as a therapeutic target in these conditions.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2 (PubMed : 11012666, PubMed : 12534281, PubMed : 12662155, PubMed : 15039077, PubMed : 15664838, PubMed : 20536396, PubMed : 29382749). Acts as a key inhibitor of caspase-1-dependent monocyte and macrophage pyroptosis in resting cells by preventing activation of NLRP1 and CARD8 (PubMed : 27820798, PubMed : 29967349, PubMed : 32796818). Sequesters the cleaved C-terminal part of NLRP1 and CARD8, which respectively constitute the active part of the NLRP1 and CARD8 inflammasomes, in a ternary complex, thereby preventing their oligomerization and activation (PubMed : 33731929, PubMed : 33731932, PubMed : 34019797). The dipeptidyl peptidase activity is required to suppress NLRP1 and CARD8; however, neither NLRP1 nor CARD8 are bona fide substrates of DPP8, suggesting the existence of substrate(s) required for NLRP1 and CARD8 inhibition (By similarity).

See full target information DPP8

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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Inflammation 39:413-424 PubMed26454447

2015

The Dipeptidyl Peptidases 4, 8, and 9 in Mouse Monocytes and Macrophages: DPP8/9 Inhibition Attenuates M1 Macrophage Activation in Mice.

Applications

Unspecified application

Species

Unspecified reactive species

Yannick Waumans,Gwendolyn Vliegen,Lynn Maes,Miche Rombouts,Ken Declerck,Pieter Van Der Veken,Wim Vanden Berghe,Guido R Y De Meyer,Dorien Schrijvers,Ingrid De Meester

Biochimica et biophysica acta 1804:781-8 PubMed20026260

2009

Dipeptidyl peptidase 9 (DPP9) from bovine testes: identification and characterization as the short form by mass spectrometry.

Applications

Species

Cow

Véronique Dubois,Anne-Marie Lambeir,Stefaan Vandamme,Veerle Matheeussen,Yves Guisez,Simon Scharpé,Ingrid De Meester

The journal of histochemistry and cytochemistry : 57:531-41 PubMed19188489

2009

Enzyme activity and immunohistochemical localization of dipeptidyl peptidase 8 and 9 in male reproductive tissues.

Applications

Unspecified application

Species

Unspecified reactive species

Véronique Dubois,Chris Van Ginneken,Hilde De Cock,Anne-Marie Lambeir,Pieter Van der Veken,Koen Augustyns,Xin Chen,Simon Scharpé,Ingrid De Meester

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-DPP8 antibody - Aminoterminal end

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Specificity

Reactivity data

Product details

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (3)

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