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AB191916

Anti-DRAGON antibody

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(1 Publication)

Rabbit Polyclonal DRAGON antibody. Suitable for WB and reacts with Human, Mouse, Rat samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human RGM domain family member B.

View Alternative Names

Repulsive guidance molecule B, DRG11-responsive axonal guidance and outgrowth of neurite, DRAGON, RGMB

1 Images
Western blot - Anti-DRAGON antibody (AB191916)
  • WB

Supplier Data

Western blot - Anti-DRAGON antibody (AB191916)

All lanes:

Western blot - Anti-DRAGON antibody (ab191916)

Lane 1:

HEK293T whole cell lysate

Lane 2:

NIH 3T3 whole cell lysate

Lane 3:

H9C2 whole cell lysate

Predicted band size: 48 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Rat, Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human RGM domain family member B. The exact immunogen used to generate this antibody is proprietary information.

Q6NW40

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
ab191916 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage buffer
pH: 7.2 Preservative: 0.05% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

DRAGON also known as Repulsive Guidance Molecule b (RGMb) is a glycoprotein involved in the regulation of signaling pathways. It weighs approximately 50 kDa and is widely expressed in various tissues including the central nervous system liver and developing limbs. As a prominent member of the RGM family DRAGON plays a part in critical cellular processes such as growth and differentiation although the detailed mechanical actions require further exploration.
Biological function summary

This protein is significant in iron metabolism and the bone morphogenetic protein (BMP) signaling pathway. It acts not only independently but also as part of a complex with the BMP receptors playing roles in embryogenesis and neurodevelopment. Its binding properties enable it to modulate BMP signals important in processes like bone formation and neural patterning.

Pathways

DRAGON interacts primarily within the BMP signaling pathway and the hepcidin pathway. By coupling with BMPs such as BMP-2 and BMP-6 DRAGON influences processes like cellular growth and apoptosis guide. Its participation in the hepcidin pathway impacts iron homeostasis as it potentially regulates hepcidin an essential hormone produced by the liver that governs iron absorption and distribution in the body. These interactions highlight DRAGON's role in coordinating complex biological activities alongside proteins like hemojuvelin and neogenin.

DRAGON's dysfunction links to conditions like anemia and cancer. Abnormalities in its expression or interaction may result in improper iron metabolism seen in anemia of chronic disease. Further its role in BMP signaling connects it to oncogenic processes contributing to tumor development in cancer. The interaction with other proteins such as BMPs and neogenin suggests that modulation of these pathways could present therapeutic avenues in diseases linked to DRAGON dysregulation.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Member of the repulsive guidance molecule (RGM) family that contributes to the patterning of the developing nervous system (By similarity). Acts as a bone morphogenetic protein (BMP) coreceptor that potentiates BMP signaling (By similarity). Promotes neuronal adhesion (By similarity). May inhibit neurite outgrowth.
See full target information RGM domain family member B
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Cell death discovery 11:292 PubMed40593474

2025

MCM9 deficiency impairs DNA damage repair during spermatogenesis, leading to Sertoli cell-only syndrome in humans.

Applications

Unspecified application

Species

Unspecified reactive species

Xuan Sha,Xin Zhang,Hao Geng,Yuqian Li,Xun Xia,Guotong Li,Rong Hua,Kuokuo Li,Yang Gao,Qunshan Shen,Rui Guo,Yuping Xu,Xiaojin He,Yunxia Cao,Mingxi Liu,Huan Wu
View all publications
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Product promise

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