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AB208160

Anti-DRAM antibody

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(5 Publications)

Rabbit Polyclonal DRAM antibody. Suitable for WB and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Recombinant Fragment Protein within Human DRAM1 aa 1-250.

View Alternative Names

DRAM, DRAM1, DNA damage-regulated autophagy modulator protein 1, Damage-regulated autophagy modulator

1 Images
Western blot - Anti-DRAM antibody (AB208160)
  • WB

Supplier Data

Western blot - Anti-DRAM antibody (AB208160)

All lanes:

Western blot - Anti-DRAM antibody (ab208160) at 4 µg/mL

Lane 1:

Human kidney lysate

Lane 2:

Human lung lysate

Predicted band size: 26 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Human DRAM1 aa 1-250. The exact immunogen used to generate this antibody is proprietary information.

Q8N682

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "4 µg/mL", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
Preservative: 0.05% Sodium azide Constituents: PBS, 0.05% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The DRAM (Damage-Regulated Autophagy Modulator) protein also known by its alternate name "drum" plays a significant role in the regulation of autophagy. DRAM serves as an effector molecule that interacts with specific molecular pathways to control cell self-digestion processes. Its molecular weight falls within the range typical for small regulatory proteins. Expression of DRAM mainly occurs in various tissues with a higher presence observed in human epithelial tissues.
Biological function summary

DRAM facilitates the autophagy process which is critical for cellular homeostasis and balancing the degradation and recycling of cellular components. It functions closely with other autophagy-related proteins forming part of a complex that includes well-studied regulators like ULK1 and LAMP2. The modulation of autophagic activity by DRAM has implications for both normal cellular processes and the response to cellular stresses.

Pathways

The product of the DRAM gene integrates into the autophagic mechanisms where it acts to enhance degradation of defective proteins and organelles. It has associations within the p53 signaling pathway through which it mediates apoptosis and autophagy. Proteins such as p53 and BCL-2 are closely related to the action of DRAM influencing cellular fate decisions during stress conditions.

DRAM's role in autophagy links it to cancer and neurodegenerative diseases. Upregulated DRAM expression is frequently observed in tumor cells where it may influence cancer progression by modulating cell survival pathways. Additionally dysregulated autophagy involving DRAM has connections to Alzheimer's disease potentially due to interactions with proteins like APP which undergo autophagic degradation processes that this protein modulates.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Lysosomal modulator of autophagy that plays a central role in p53/TP53-mediated apoptosis. Not involved in p73/TP73-mediated autophagy.
See full target information DRAM1
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Publications (5)

Recent publications for all applications. Explore the full list and refine your search

Scientific reports 15:3542 PubMed39875526

2025

DRAM1 enhances the proliferation and metastasis of gastric cancer through the PI3K/AKT/mTOR signaling pathway and energy metabolism.

Applications

Unspecified application

Species

Unspecified reactive species

Xinrong Wu,Yifan Li,Weiwei Wang,Jiale Xu,Bei Zhao,Wenqi Sun,Dan Ge,Longying Xiong,Xiaotan Dou,Xiaoping Zou,Lei Wang,Min Chen

Autophagy 18:2636-2655 PubMed35427207

2022

ATF3 -activated accelerating effect of LINC00941/lncIAPF on fibroblast-to-myofibroblast differentiation by blocking autophagy depending on ELAVL1/HuR in pulmonary fibrosis.

Applications

Unspecified application

Species

Unspecified reactive species

Jinjin Zhang,Haixia Wang,Hongbin Chen,Hongbo Li,Pan Xu,Bo Liu,Qian Zhang,Changjun Lv,Xiaodong Song

Journal of oncology 2022:4402536 PubMed35222643

2022

EGFR-AS1 Promotes Nonsmall Cell Lung Cancer (NSCLC) Progression via Downregulating the miR-524-5p/DRAM1 Axis and Inhibiting Autophagic Lysosomal Degradation.

Applications

Unspecified application

Species

Unspecified reactive species

Yang Xue,Jing Zhang,Jiguang Hou,Xin Wang

Experimental and therapeutic medicine 17:4032-4038 PubMed30988784

2019

Downregulation of microRNA-425-5p suppresses cervical cancer tumorigenesis by targeting AIFM1.

Applications

Unspecified application

Species

Unspecified reactive species

Ying Zhang,Yuxiu Yang,Rongxia Liu,Yucui Meng,Geng Tian,Qinying Cao

Journal of cellular physiology 234:5023-5032 PubMed30203495

2018

Effect of autophagy gene DRAM on proliferation, cell cycle, apoptosis, and autophagy of osteoblast in osteoporosis rats.

Applications

Unspecified application

Species

Unspecified reactive species

Ning Tang,Hong Zhao,Hengyan Zhang,Yulei Dong
View all publications
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Product promise

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