AB20424

Anti-DRD4 antibody

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(5 Publications)

Rabbit Polyclonal DRD4 antibody. Suitable for ICC, WB, IHC-P, ICC/IF and reacts with Rat samples. Cited in 5 publications.

View Alternative Names

D(4) dopamine receptor, D(2C) dopamine receptor, Dopamine D4 receptor, DRD4

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Rat

Applications

WB, ICC, ICC/IF, IHC-P

applications

Immunogen

Synthetic Peptide within Human DRD4 aa 150-200. The exact immunogen used to generate this antibody is proprietary information.

P21917

Specificity

Cross-reactivity:D4 Dopamine Receptor (176-185) 100%D4 Dopamine Receptor 60%D1 Dopamine Receptor (9-21) 0%D1 Dopamine Receptor 0%D2 Dopamine Receptor (272-282) 0%D2 Dopamine Receptor 0%D3 Dopamine Receptor (2-10) 0%D3 Dopamine Receptor 0%D5 Dopamine Receptor (23-35) 0%D5 Dopamine Receptor 0%

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICC" : {"fullname" : "Immunocytochemistry", "shortname":"ICC"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Rat": { "ICC-species-checked": "guaranteed", "ICC-species-dilution-info": "", "ICC-species-notes": "", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purity

Whole antiserum

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The Dopamine Receptor D4 (DRD4) is a protein known for its role as a receptor in the central nervous system. It is part of the dopamine receptor family which plays a critical role in neurotransmission. DRD4 is encoded by the DRD4 gene and has a mass of approximately 48 kDa. This receptor is commonly expressed in the brain particularly in areas such as the prefrontal cortex. It binds dopamine an important neurotransmitter which leads to the activation of intracellular signaling cascades.

Biological function summary

The DRD4 receptor is involved in modulating neuronal excitability and synaptic plasticity. It belongs to the G protein-coupled receptor complex which is essential for transmitting signals across cell membranes. Upon dopamine binding DRD4 inhibits the production of a secondary messenger called cyclic AMP affecting processes like learning memory and attention. It plays a significant role in the reward system influencing behavior and mood.

Pathways

DRD4 interacts with the dopamine signaling pathway which influences several physiological processes including motor control and emotional response. It also plays a part in the regulation of cyclic AMP working closely with proteins such as adenylate cyclase. The DRD4 receptor works within the dopaminergic pathway contributing to a complex network involved in neurological and psychiatric functions.

DRD4 has been linked to attention deficit hyperactivity disorder (ADHD) and schizophrenia. Variations in the DRD4 gene are associated with an increased risk of these conditions. The receptor’s function in dopamine signaling connects it to other proteins like D2 and D3 receptors which also influence these neuropsychiatric disorders. Its involvement in dopamine regulation makes it a potential target for pharmacological treatments aimed at managing symptoms and modifying disease progression.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Dopamine receptor responsible for neuronal signaling in the mesolimbic system of the brain, an area of the brain that regulates emotion and complex behavior. Activated by dopamine, but also by epinephrine and norepinephrine, and by numerous synthetic agonists and drugs (PubMed : 16423344, PubMed : 27659709, PubMed : 29051383, PubMed : 9003072). Agonist binding triggers signaling via G proteins that inhibit adenylyl cyclase (PubMed : 16423344, PubMed : 27659709, PubMed : 29051383, PubMed : 7512953, PubMed : 7643093). Modulates the circadian rhythm of contrast sensitivity by regulating the rhythmic expression of NPAS2 in the retinal ganglion cells (By similarity).

See full target information DRD4

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Publications (5)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in psychiatry 12:645081 PubMed33776821

2021

Expression of Dopamine D and Serotonin 5-HT Receptors in Blood Mononuclear Cells in Schizophrenia.

Applications

Unspecified application

Species

Unspecified reactive species

Adam Wysokiński,Elżbieta Kozłowska,Ewa Szczepocka,Anna Łucka,Justyna Agier,Ewa Brzezińska-Błaszczyk,Katarzyna Sobierajska

The European journal of neuroscience 52:4563-4585 PubMed33098606

2020

Dopamine D4 receptor modulates inhibitory transmission in pallido-pallidal terminals and regulates motor behavior.

Applications

Unspecified application

Species

Unspecified reactive species

Israel Conde Rojas,Jackeline Acosta-García,Rene Nahum Caballero-Florán,Rafael Jijón-Lorenzo,Sergio Recillas-Morales,José Arturo Avalos-Fuentes,Francisco Paz-Bermúdez,Gerardo Leyva-Gómez,Hernán Cortés,Benjamín Florán

Brain and behavior 10:e01694 PubMed32525610

2020

Sex-dependent alterations of dopamine receptor and glucose transporter density in rat hypothalamus under long-term clozapine and haloperidol medication.

Applications

Unspecified application

Species

Unspecified reactive species

Marie-Luise Bouvier,Karin Fehsel,Andrea Schmitt,Eva Meisenzahl-Lechner,Wolfgang Gaebel,Martina von Wilmsdorff

Biochemical and biophysical research communications 417:197-203 PubMed22155235

2011

Cellular localization of dopamine receptors in the gastric mucosa of rats.

Applications

IHC-P

Species

Rat

Qian Wang,Tuo Ji,Li-Fei Zheng,Xiao-Yan Feng,Zhi-Yong Wang,Hui Lian,Jin Song,Xiao-Feng Li,Yue Zhang,Jin-Xia Zhu

The European journal of neuroscience 31:1027-42 PubMed20377617

2010

Dopamine receptor mechanisms mediate corticotropin-releasing factor-induced long-term potentiation in the rat amygdala following cocaine withdrawal.

Applications

Unspecified application

Species

Unspecified reactive species

Balaji Krishnan,Marjorie Centeno,Sebastian Pollandt,Yu Fu,Kathy Genzer,Jie Liu,Joel P Gallagher,Patricia Shinnick-Gallagher

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-DRD4 antibody

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Specificity

Alternative Products

Primary Antibodies

Complementary Products

Primary Antibodies

Primary Antibodies

Secondary Antibodies

Primary Antibodies

Reactivity data

Properties and storage information

Form

Purity

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (5)

Product promise