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AB40656

Anti-DRD5 antibody

3

(2 Reviews)

|

(2 Publications)

Rabbit Polyclonal DRD5 antibody. Suitable for Flow Cyt, WB, ICC/IF and reacts with Rat samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human DRD5 aa 1-50 conjugated to Keyhole Limpet Haemocyanin.

View Alternative Names

DRD1B, DRD1L2, DRD5, D(1B) dopamine receptor, D(5) dopamine receptor, D1beta dopamine receptor, Dopamine D5 receptor

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Rat

Applications

Flow Cyt, WB, ICC/IF

applications

Immunogen

Synthetic Peptide within Human DRD5 aa 1-50 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

P21918

Specificity

Cross-reacts with Human D5 Dopamine Receptor(Ac23-35) 100%, D5 Dopamine Receptor 80%. Does not cross react with other dopamine receptors (D1, D2, D3, D4).

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "predicted", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "FlowCyt-species-checked": "guaranteed", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "<p><a href='/en-us/products/primary-antibodies/rabbit-igg-polyclonal-isotype-control-chip-grade-ab171870'>ab171870</a> - Rabbit polyclonal IgG, is suitable for use as an isotype control with this antibody.</p>", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p>Blocking with 5% goat or donkey serum significantly reduces background as compared to BSA or milk.</p>", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "<p></p>" }, "Gorilla": { "FlowCyt-species-checked": "predicted", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Properties and storage information

Form
Lyophilized
Reconstitution
reconstitute with PBS, 10 mg/mL BSA at 0.1mL
Purity
Whole antiserum
Storage buffer
Constituents: Whole serum
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

DRD5 also known as dopamine receptor D5 is a protein encoded by the DRD5 gene. It is part of the D1-like receptor family and selectively binds dopamine with high affinity. DRD5 is a G-protein coupled receptor (GPCR) involved in the activation of adenylyl cyclase which increases cyclic AMP levels in the cell. The protein has a mass of approximately 53 kDa and is mainly expressed in the central nervous system including regions such as the frontal cortex basal ganglia and limbic system.
Biological function summary

DRD5 plays an important role in modulating neurotransmission and influencing behavior and cognition. It interacts with other dopamine receptors and is not generally considered to form stable complexes but it can be part of transient signaling complexes during signaling events. Its function impacts motor control emotional response and cognitive functions such as learning and memory by modulating synaptic plasticity and neural circuit activity.

Pathways

DRD5 is an important component of dopamine signaling cascades particularly those impacting the cAMP-PKA pathway. This pathway influences neuronal excitability and synaptic transmission. DRD5 works alongside other dopamine receptors particularly dopamine receptor D1 (DRD1) to mediate these effects. The signaling through DRD5 and DRD1 plays a role in pathways regulating the reward system and motor control impacting behavior and movement.

DRD5 has been implicated in neurological and psychiatric conditions. One example is schizophrenia where dysregulation of dopamine signaling involving DRD5 and DRD2 contributes to pathophysiology. Another condition is Parkinson's disease characterized by motor dysfunction where alterations in dopamine receptor activity including DRD5 impact disease progression. Understanding DRD5’s role provides insight into the mechanistic pathways of these disorders and potential therapeutic approaches.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.
See full target information DRD5
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

The international journal of neuropsychopharmacology 20:257-268 PubMed27815417

2016

Dopamine D1 and D3 Receptors Modulate Heroin-Induced Cognitive Impairment through Opponent Actions in Mice.

Applications

Unspecified application

Species

Unspecified reactive species

Yongsheng Zhu,Yunpeng Wang,Jianghua Lai,Shuguang Wei,Hongbo Zhang,Peng Yan,Yunxiao Li,Xiaomeng Qiao,Fangyuan Yin

Movement disorders : official journal of the Movem 28:1351-9 PubMed23674405

2013

Variability in neuronal expression of dopamine receptors and transporters in the substantia nigra.

Applications

Unspecified application

Species

Unspecified reactive species

Stefanie Reyes,Veronica Cottam,Deniz Kirik,Kay L Double,Glenda M Halliday
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions
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Associated Products

Select an associated product type
Alternative Product
Primary Antibodies

AB181623

Anti-DRD5 antibody - C-terminal

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drd5-antibody-c-terminal-ab181623

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Alternative Product
Primary Antibodies

AB32620

Anti-DRD5 antibody

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drd5-antibody-ab32620

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