Rabbit Polyclonal DRD5 antibody. Suitable for Flow Cyt, WB, ICC/IF and reacts with Rat samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human DRD5 aa 1-50 conjugated to Keyhole Limpet Haemocyanin.
IgG
Rabbit
Constituents: Whole serum
Lyophilized
Polyclonal
| Flow Cyt | WB | ICC/IF | |
|---|---|---|---|
| Human | Predicted | Predicted | Predicted |
| Rat | Expected | Expected | Expected |
| Gorilla | Predicted | Predicted | Predicted |
| Species | Dilution info | Notes |
|---|---|---|
Species Rat | Dilution info - | Notes ab171870 - Rabbit polyclonal IgG, is suitable for use as an isotype control with this antibody. |
| Species | Dilution info | Notes |
|---|---|---|
Species Human, Gorilla | Dilution info - | Notes - |
| Species | Dilution info | Notes |
|---|---|---|
Species Rat | Dilution info - | Notes Blocking with 5% goat or donkey serum significantly reduces background as compared to BSA or milk. |
| Species | Dilution info | Notes |
|---|---|---|
Species Human, Gorilla | Dilution info - | Notes - |
| Species | Dilution info | Notes |
|---|---|---|
Species Rat | Dilution info Use at an assay dependent concentration. | Notes - |
| Species | Dilution info | Notes |
|---|---|---|
Species Human, Gorilla | Dilution info - | Notes - |
Select an associated product type
Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.
DRD1B, DRD1L2, DRD5, D(1B) dopamine receptor, D(5) dopamine receptor, D1beta dopamine receptor, Dopamine D5 receptor
Rabbit Polyclonal DRD5 antibody. Suitable for Flow Cyt, WB, ICC/IF and reacts with Rat samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human DRD5 aa 1-50 conjugated to Keyhole Limpet Haemocyanin.
IgG
Rabbit
Constituents: Whole serum
Lyophilized
Polyclonal
Whole antiserum
Cross-reacts with Human D5 Dopamine Receptor(Ac23-35) 100%, D5 Dopamine Receptor 80%. Does not cross react with other dopamine receptors (D1, D2, D3, D4).
reconstitute with PBS, 10 mg/mL BSA at 0.1mL
Blue Ice
+4°C
-20°C
Avoid freeze / thaw cycle
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This supplementary information is collated from multiple sources and compiled automatically.
DRD5 also known as dopamine receptor D5 is a protein encoded by the DRD5 gene. It is part of the D1-like receptor family and selectively binds dopamine with high affinity. DRD5 is a G-protein coupled receptor (GPCR) involved in the activation of adenylyl cyclase which increases cyclic AMP levels in the cell. The protein has a mass of approximately 53 kDa and is mainly expressed in the central nervous system including regions such as the frontal cortex basal ganglia and limbic system.
DRD5 plays an important role in modulating neurotransmission and influencing behavior and cognition. It interacts with other dopamine receptors and is not generally considered to form stable complexes but it can be part of transient signaling complexes during signaling events. Its function impacts motor control emotional response and cognitive functions such as learning and memory by modulating synaptic plasticity and neural circuit activity.
DRD5 is an important component of dopamine signaling cascades particularly those impacting the cAMP-PKA pathway. This pathway influences neuronal excitability and synaptic transmission. DRD5 works alongside other dopamine receptors particularly dopamine receptor D1 (DRD1) to mediate these effects. The signaling through DRD5 and DRD1 plays a role in pathways regulating the reward system and motor control impacting behavior and movement.
DRD5 has been implicated in neurological and psychiatric conditions. One example is schizophrenia where dysregulation of dopamine signaling involving DRD5 and DRD2 contributes to pathophysiology. Another condition is Parkinson's disease characterized by motor dysfunction where alterations in dopamine receptor activity including DRD5 impact disease progression. Understanding DRD5’s role provides insight into the mechanistic pathways of these disorders and potential therapeutic approaches.
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This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
We do not recommend this combination. It is not covered by our product promise.
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