AB181623

Anti-DRD5 antibody - C-terminal

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(2 Publications)

Rabbit Polyclonal DRD5 antibody. C-terminal. Suitable for WB and reacts with Rat, Mouse samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Mouse Drd5 aa 350-450.

View Alternative Names

D(1B) dopamine receptor, D(5) dopamine receptor, Dopamine D5 receptor, Drd5

1 Images

Supplier Data

Western blot - Anti-DRD5 antibody - C-terminal (AB181623)

All lanes:

Western blot - Anti-DRD5 antibody - C-terminal (ab181623) at 0.5 µg

Lane 1:

rat brain tissue at 50 µg

Lane 2:

mouse brain tissue at 50 µg

Secondary

All lanes:

Goat anti-rabbit IgG-HRP at 1/10000 dilution

Predicted band size: 53 kDa

true

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Mouse, Rat

Applications

applications

Immunogen

Synthetic Peptide within Mouse Drd5 aa 350-450. The exact immunogen used to generate this antibody is proprietary information.

Q8BLD9

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.1-0.5 µg/mL", "WB-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.1-0.5 µg/mL", "WB-species-notes": "<p></p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

Preservative: 0.025% Sodium azide, 0.025% Thimerosal (merthiolate) Constituents: 2.5% BSA, 0.45% Sodium chloride, 0.1% Disodium hydrogenorthophosphate

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

DRD5 also known as dopamine receptor D5 is a protein encoded by the DRD5 gene. It is part of the D1-like receptor family and selectively binds dopamine with high affinity. DRD5 is a G-protein coupled receptor (GPCR) involved in the activation of adenylyl cyclase which increases cyclic AMP levels in the cell. The protein has a mass of approximately 53 kDa and is mainly expressed in the central nervous system including regions such as the frontal cortex basal ganglia and limbic system.

Biological function summary

DRD5 plays an important role in modulating neurotransmission and influencing behavior and cognition. It interacts with other dopamine receptors and is not generally considered to form stable complexes but it can be part of transient signaling complexes during signaling events. Its function impacts motor control emotional response and cognitive functions such as learning and memory by modulating synaptic plasticity and neural circuit activity.

Pathways

DRD5 is an important component of dopamine signaling cascades particularly those impacting the cAMP-PKA pathway. This pathway influences neuronal excitability and synaptic transmission. DRD5 works alongside other dopamine receptors particularly dopamine receptor D1 (DRD1) to mediate these effects. The signaling through DRD5 and DRD1 plays a role in pathways regulating the reward system and motor control impacting behavior and movement.

DRD5 has been implicated in neurological and psychiatric conditions. One example is schizophrenia where dysregulation of dopamine signaling involving DRD5 and DRD2 contributes to pathophysiology. Another condition is Parkinson's disease characterized by motor dysfunction where alterations in dopamine receptor activity including DRD5 impact disease progression. Understanding DRD5’s role provides insight into the mechanistic pathways of these disorders and potential therapeutic approaches.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.

See full target information Drd5

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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in neurology 12:653321 PubMed34413820

2021

miR-124-3p Inhibits Microglial Secondary Inflammation After Basal Ganglia Hemorrhage by Targeting TRAF6 and Repressing the Activation of NLRP3 Inflammasome.

Applications

Unspecified application

Species

Unspecified reactive species

Yudan Fang,Xiaoqin Hong

Molecular psychiatry 26:2514-2532 PubMed33303946

2020

ZFP804A mutant mice display sex-dependent schizophrenia-like behaviors.

Applications

Unspecified application

Species

Unspecified reactive species

Ying Huang,Jing Huang,Qi-Xin Zhou,Chun-Xian Yang,Cui-Ping Yang,Wan-Ying Mei,Lei Zhang,Qiong Zhang,Ling Hu,Yun-Qing Hu,Ning-Ning Song,Sheng-Xi Wu,Lin Xu,Yu-Qiang Ding

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-DRD5 antibody - C-terminal

Western blot - Anti-DRD5 antibody - C-terminal (AB181623)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (2)

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