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AB236958

Anti-DRG1 antibody

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(1 Publication)

Rabbit Polyclonal DRG1 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human DRG1 aa 150-250.

View Alternative Names

NEDD3, DRG1, Developmentally-regulated GTP-binding protein 1, DRG-1, Neural precursor cell expressed developmentally down-regulated protein 3, Translation factor GTPase DRG1, NEDD-3, TRAFAC GTPase DRG1

4 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DRG1 antibody (AB236958)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DRG1 antibody (AB236958)

Paraffin-embedded human kidney tissue stained for DRG1 using ab236958 at 1/100 dilution in immunohistochemical analysis.

Immunocytochemistry/ Immunofluorescence - Anti-DRG1 antibody (AB236958)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-DRG1 antibody (AB236958)

HepG2 (human liver hepatocellular carcinoma cell line) cells stained for DRG1 (green) using ab236958 at 1/100 dilution in ICC/IF, followed by Alexa Fluor 488-conjugated goat anti-rabbit IgG (H+L).

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DRG1 antibody (AB236958)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DRG1 antibody (AB236958)

Paraffin-embedded human placenta tissue stained for DRG1 using ab236958 at 1/100 dilution in immunohistochemical analysis.

Western blot - Anti-DRG1 antibody (AB236958)
  • WB

Supplier Data

Western blot - Anti-DRG1 antibody (AB236958)

All lanes:

Western blot - Anti-DRG1 antibody (ab236958) at 1/200 dilution

All lanes:

HepG2 (human liver hepatocellular carcinoma cell line) whole cell lysate

Secondary

All lanes:

Goat polyclonal to rabbit IgG at 1/50000 dilution

Predicted band size: 41 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF, WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human DRG1 aa 150-250. The exact immunogen used to generate this antibody is proprietary information.

Q9Y295

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/200 - 1/5000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/50 - 1/200", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Purity >95%.
Storage buffer
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The DRG1 protein also known as Developmentally Regulated GTP-binding protein 1 is an important player in cellular functions. This highly conserved protein has a mass of approximately 42 kDa and is expressed in various tissues including the brain and testis indicating its essential role in different biological processes. It contains GTP-binding motifs important for its activity which allows the protein to interact with other molecular partners in the cell facilitating its participation in cellular events.
Biological function summary

DRG1 engages in several critical cellular processes beyond its mechanical functions. One of its notable roles involves contributions to ribosome biogenesis although it does not form a permanent complex with the ribosome. The protein supports cellular growth and division highlighting its potential in affecting cell cycle regulation. DRG1 associates transiently with other proteins allowing it to influence a range of biological functions including cellular growth signaling pathways.

Pathways

Research indicates that DRG1 links to important regulatory networks such as the Ras signaling and translational control pathways. Within these pathways DRG1 interacts with proteins like eukaryotic initiation factors which are important for translation regulation. This interaction plays a role in coordinating protein synthesis which supports overall cellular growth and response to environmental cues. Understanding its place in these pathways sheds light on how cells control protein production and growth.

Studies suggest DRG1's involvement in cancer and neurological disorders. In certain cancers altered expression of DRG1 correlates with tumor progression implicating its role in cell proliferation and survival mechanisms. Additionally DRG1 has connections to neurodegenerative disorders potentially through interactions with tau protein which is associated with abnormal protein deposits in the brain. The protein's link to these diseases highlights the need for further research into its functional mechanisms and potential as a therapeutic target.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Catalyzes the conversion of GTP to GDP through hydrolysis of the gamma-phosphate bond in GTP (PubMed : 23711155, PubMed : 29915238, PubMed : 37179472). Appears to have an intrinsic GTPase activity that is stimulated by ZC3H15/DFRP1 binding likely by increasing the affinity for the potassium ions (PubMed : 23711155). When hydroxylated at C-3 of 'Lys-22' by JMJD7, may bind to RNA and play a role in translation (PubMed : 19819225, PubMed : 29915238). Binds to microtubules and promotes microtubule polymerization and stability that are required for mitotic spindle assembly during prophase to anaphase transition. GTPase activity is not necessary for these microtubule-related functions (PubMed : 28855639).
See full target information DRG1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

The Journal of clinical investigation 135: PubMed39817450

2025

Clonal analysis of SepSecS-specific B and T cells in autoimmune hepatitis.

Applications

Unspecified application

Species

Unspecified reactive species

Michael Kramer,Federico Mele,Sandra Jovic,Blanca Maria Fernandez,David Jarrossay,Jun Siong Low,Christiane Sokollik,Magdalena Filipowicz Sinnreich,Sylvie Ferrari-Lacraz,Giorgina Mieli-Vergani,Diego Vergani,Antonio Lanzavecchia,Antonino Cassotta,Benedetta Terziroli Beretta-Piccoli,Federica Sallusto
View all publications
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Product promise

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