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AB127170

Anti-DRG2 antibody

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(1 Publication)

Rabbit Polyclonal DRG2 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human DRG2 aa 50-300.

View Alternative Names

Developmentally-regulated GTP-binding protein 2, DRG-2, Translation factor GTPase DRG2, TRAFAC GTPase DRG2, DRG2

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DRG2 antibody (AB127170)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DRG2 antibody (AB127170)

ab127170, at 1/500 dilution, staining Human DRG2 in paraffin-embedded lung cancer tissue by immunohistochemistry

Western blot - Anti-DRG2 antibody (AB127170)
  • WB

Unknown

Western blot - Anti-DRG2 antibody (AB127170)

10% SDS PAGE

All lanes:

Western blot - Anti-DRG2 antibody (ab127170) at 1/1000 dilution

All lanes:

Jurkat whole cell lysate at 30 µg

Predicted band size: 41 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human DRG2 aa 50-300. The exact immunogen used to generate this antibody is proprietary information.

P55039

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/500", "IHCP-species-notes": "<p>Alternatively Tris-EDTA buffer ( pH8.0) may be used.</p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: PBS, 20% Glycerol (glycerin, glycerine), 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

DRG2 also known as Developmentally Regulated GTP Binding Protein 2 is a small GTPase with a molecular mass of approximately 42 kDa. It is expressed in various tissues including the brain and muscle indicating its potential roles in different cellular functions. DRG2 belongs to the DRG family which consists of evolutionarily conserved proteins within the GTP-binding protein superfamily. As a GTPase DRG2 is involved in the mechanical process of hydrolyzing GTP to GDP which is important for its functions and regulatory activities within the cell.
Biological function summary

DRG2 functions in cellular growth and proliferation. It participates as part of protein complexes that include other GTPases and cofactors which modulate its activity and stability. In addition to basic cellular proliferation DRG2 also plays a role in the regulation of the cell cycle and differentiation. This protein has been noted to have interactions that could influence cellular responses to stress and regulation of translational machinery.

Pathways

DRG2 is involved in the regulation of the cell cycle and translational control pathways. It interacts with other proteins like DRG1 and ZBP1 which are significant in regulating translation and maintaining cellular homeostasis. DRG2 plays a part in ensuring proper cell division and protein synthesis integrating signals from growth factors and environmental conditions. It is important for fine-tuning protein production corresponding to cellular needs and states ensuring cells respond correctly to signals.

DRG2 has associations with several conditions including cancer and neurodegenerative diseases. For instance aberrant expression or mutation of DRG2 leads to disruptions in cell proliferation which may contribute to tumorigenesis. In cancer DRG2 interacts with pathways and proteins like p53 which are key in tumor suppression. On the neurodegenerative front altered pathways involving DRG2 could impact neuronal survivability and function. These connections suggest that DRG2 might serve as a marker or potential target for therapeutic intervention in these diseases.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Catalyzes the conversion of GTP to GDP through hydrolysis of the gamma-phosphate bond in GTP. When hydroxylated at C-3 of 'Lys-21' by JMJD7, may bind to RNA and play a role in translation.
See full target information DRG2
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Life science alliance 7: PubMed38803224

2024

K48- and K63-linked ubiquitin chain interactome reveals branch- and length-specific ubiquitin interactors.

Applications

Unspecified application

Species

Unspecified reactive species

Anita Waltho,Oliver Popp,Christopher Lenz,Lukas Pluska,Mahil Lambert,Volker Dötsch,Philipp Mertins,Thomas Sommer
View all publications
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