Anti-DRG2 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

DRG2 also known as Developmentally Regulated GTP Binding Protein 2 is a small GTPase with a molecular mass of approximately 42 kDa. It is expressed in various tissues including the brain and muscle indicating its potential roles in different cellular functions. DRG2 belongs to the DRG family which consists of evolutionarily conserved proteins within the GTP-binding protein superfamily. As a GTPase DRG2 is involved in the mechanical process of hydrolyzing GTP to GDP which is important for its functions and regulatory activities within the cell.

Biological function summary

DRG2 functions in cellular growth and proliferation. It participates as part of protein complexes that include other GTPases and cofactors which modulate its activity and stability. In addition to basic cellular proliferation DRG2 also plays a role in the regulation of the cell cycle and differentiation. This protein has been noted to have interactions that could influence cellular responses to stress and regulation of translational machinery.

Pathways

DRG2 is involved in the regulation of the cell cycle and translational control pathways. It interacts with other proteins like DRG1 and ZBP1 which are significant in regulating translation and maintaining cellular homeostasis. DRG2 plays a part in ensuring proper cell division and protein synthesis integrating signals from growth factors and environmental conditions. It is important for fine-tuning protein production corresponding to cellular needs and states ensuring cells respond correctly to signals.

Associated diseases and disorders

DRG2 has associations with several conditions including cancer and neurodegenerative diseases. For instance aberrant expression or mutation of DRG2 leads to disruptions in cell proliferation which may contribute to tumorigenesis. In cancer DRG2 interacts with pathways and proteins like p53 which are key in tumor suppression. On the neurodegenerative front altered pathways involving DRG2 could impact neuronal survivability and function. These connections suggest that DRG2 might serve as a marker or potential target for therapeutic intervention in these diseases.