Anti-Drosophila FMR1 antibody [6A15]

Target data

Polyribosome-associated RNA-binding protein that plays a role in neuronal development and synaptic plasticity through the regulation of protein synthesis of mRNAs (PubMed : 11046149, PubMed : 11733059, PubMed : 12368261, PubMed : 17178403). Acts as an mRNA regulator by mediating formation of some phase-separated membraneless compartment : undergoes liquid-liquid phase separation upon binding to target mRNAs, leading to assemble mRNAs into cytoplasmic ribonucleoprotein granules that concentrate mRNAs with associated regulatory factors (PubMed : 35165263). Mainly acts as an activator of mRNA translation : promotes translation of stored mRNAs in oocytes (PubMed : 30115809). Can also act as a negative translational regulator of specific mRNAs (PubMed : 11733059, PubMed : 17178403). Represses translation of the microtubule-associated protein futsch mRNA to regulate microtubule-dependent synaptic growth and function (PubMed : 11733059). Localizes to specific N6-methyladenosine (m6A)-containing RNAs as part of a complex with the m6A reader Ythdf and thereby regulates axonal growth in the mushroom bodies and neuromuscular junctions (PubMed : 33428246). Specifically recognizes and binds a subset of N6-methyladenosine (m6A)-containing mRNAs in embryos, promoting formation of a phase-separated membraneless compartment that mediates degradation of maternal mRNAs (PubMed : 35165263). May also be involved in microRNA (miRNA)-mediated translational suppression as part of the RNA-induced silencing complex (RISC) (PubMed : 12368261, PubMed : 14508492). Required for stability of the central pair of microtubules in the spermatid axoneme (PubMed : 15183715). Regulates photoreceptor structure and neuromuscular junction (NMJ) neurotransmission in the eye (PubMed : 11733059, PubMed : 17178403). During embryogenesis, involved in germline fate determination (PubMed : 16949822).