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AB234856

Anti-DSCR1L1 antibody

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(1 Publication)

Rabbit Polyclonal DSCR1L1 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human RCAN2 aa 50-200.

View Alternative Names

DSCR1L1, ZAKI4, RCAN2, Calcipressin-2, Down syndrome candidate region 1-like 1, Myocyte-enriched calcineurin-interacting protein 2, Regulator of calcineurin 2, Thyroid hormone-responsive protein ZAKI-4, MCIP2

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DSCR1L1 antibody (AB234856)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DSCR1L1 antibody (AB234856)

Paraffin-embedded human brain tissue stained for DSCR1L1 using ab234856 at 1/100 dilution in immunohistochemical analysis.

Immunocytochemistry/ Immunofluorescence - Anti-DSCR1L1 antibody (AB234856)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-DSCR1L1 antibody (AB234856)

A549 (Human lung carcinoma cell line) cells labeling DSCR1L1 (green) using ab234856 at 1/100 dilution in ICC/IF. Secondary antibody was an Alexa Fluor® 488-conjugated goat anti-rabbit IgG (H+L).

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

IHC-P, ICC/IF, WB

applications

Immunogen

Recombinant Fragment Protein within Human RCAN2 aa 50-200. The exact immunogen used to generate this antibody is proprietary information.

Q14206

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Alternative Products

Primary Antibodies

AB106543

Anti-DSCR1L1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DSCR1L1 antibody (AB106543)

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Complementary Products

Proteins & Peptides

AB115724

Recombinant Human DSCR1L1 protein (His tag N-Terminus)

SDS-PAGE - Recombinant Human DSCR1L1 protein (His tag N-Terminus) (AB115724)

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Primary Antibodies

AB234885

Anti-PHLDB2 antibody

Immunocytochemistry/ Immunofluorescence - Anti-PHLDB2 antibody (AB234885)

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Primary Antibodies

AB168338

Anti-CLPX antibody [EP8772]

RabMAb|Recombinant|Trial Size

Immunocytochemistry/ Immunofluorescence - Anti-CLPX antibody [EP8772] (AB168338)

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Assay Kits

AB241031

Monoamine Oxidase (MAO) Assay Kit

Functional Studies - Monoamine Oxidase (MAO) Assay Kit (AB241031)

  • 0
  • 0
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/50 - 1/200", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/5000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Chimpanzee": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Orangutan": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Purity >95%.
Storage buffer
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

DSCR1L1 also known as RCAN2 (Regulator of Calcineurin 2) is a protein with a molecular weight of approximately 25 kDa. It is encoded by the DSCR1L1 gene and widely expressed in various tissues including the brain heart and skeletal muscles. DSCR1L1 plays a role in inhibiting the phosphatase activity of calcineurin by directly interacting with it. This interaction modulates the intracellular signaling processes that are essential for diverse cellular functions.
Biological function summary

This protein plays an important role in regulating calcium-dependent signaling pathways. Although DSCR1L1 is not typically part of a multiprotein complex it influences pathways through direct and indirect interactions. By inhibiting calcineurin DSCR1L1 limits the dephosphorylation of Nuclear Factor of Activated T-cells (NFAT) proteins which are key transcription factors. This regulation is critical for diverse biological processes including immune response and muscle development.

Pathways

DSCR1L1 modulates the calcineurin-NFAT signaling pathway which is essential for the transduction of calcium signals and the subsequent regulation of gene expression. This protein's interaction with calcineurin affects the transcriptional activity of NFAT proteins which are active in many physiological processes. DSCR1L1 is also connected with the oxidative stress response pathway where it interacts with other proteins that regulate cellular stress responses.

DSCR1L1 has been implicated in neurological conditions such as Down syndrome and Alzheimer's disease. Its regulation of calcineurin activity links it with pathways affected in these disorders. DSCR1L1's relationship with calcineurin also ties it to the pathology of Alzheimer's disease where calcineurin signaling dysregulation is observed. These interactions highlight the significance of DSCR1L1 in processes that contribute to neurodevelopmental and neurodegenerative disorders.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development.
See full target information RCAN2
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Biomolecules 15: PubMed39858544

2025

Cell Type Specific Suppression of Hyper-Recombination by Human RAD18 Is Linked to Proliferating Cell Nuclear Antigen K164 Ubiquitination.

Applications

Unspecified application

Species

Unspecified reactive species

Colette B Rogers,Wendy Leung,Ryan M Baxley,Rachel E Kram,Liangjun Wang,Joseph P Buytendorp,Khoi Le,David A Largaespada,Eric A Hendrickson,Anja-Katrin Bielinsky
View all publications
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Product promise

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