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AB272929

Anti-DSPP antibody

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(1 Publication)

Rabbit Polyclonal DSPP antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human DSPP.

View Alternative Names

Dentin sialophosphoprotein, DSPP

1 Images
Western blot - Anti-DSPP antibody (AB272929)
  • WB

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Western blot - Anti-DSPP antibody (AB272929)

5% SDS-PAGE

All lanes:

Western blot - Anti-DSPP antibody (ab272929) at 1/500 dilution

All lanes:

MCF7 (Human breast adenocarcinoma cell line) whole cell extract at 30 µg

Secondary

All lanes:

HRP-conjugated anti-rabbit IgG antibody

Predicted band size: 131 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human DSPP. The exact immunogen used to generate this antibody is proprietary information.

Q9NZW4

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.025% Proclin 300 Constituents: PBS, 20% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

DSPP also known as Dentin Sialophosphoprotein is a protein important for tooth development and dentin mineralization. It has a molecular mass of about 110-130 kDa which can vary due to post-translational modifications and cleavage into its components. This protein mainly expresses in odontoblasts the cells responsible for dentin formation but is also found in other tissues like bone and inner ear. The protein shares structural similarities with other members of the SIBLING family which are known to interact with mineralized tissues.
Biological function summary

DSPP plays an essential role in the formation and maintenance of dentin structure. It first undergoes proteolytic cleavage into two main products: Dentin Sialoprotein (DSP) and Dentin Phosphoprotein (DPP). These components integrate into the extracellular matrix where they contribute to the mineralization process of dentin. DSPP does not act alone but participates in a protein complex involving other matrix molecules that help regulate mineralization.

Pathways

DSPP is a component of key mineralization pathways which ensure proper formation and hardening of dentin. One significant pathway is the Transforming Growth Factor-beta (TGF-beta) signaling pathway which influences dental tissue response during tooth development. Within this pathway DSPP interacts with proteins like Bone Morphogenetic Protein (BMP) to facilitate signaling processes required for odontoblast differentiation and function.

Mutations or dysfunctional expression of DSPP link to dental defects such as Dentinogenesis Imperfecta and dentin dysplasia. These conditions lead to abnormal dentin formation causing teeth to be discolored weak or misformed. Additionally DSPP shows interactions with proteins associated with bone disorders which suggests a role in conditions like osteogenesis imperfecta. Understanding these associations can guide therapeutic approaches in managing dental and skeletal abnormalities.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

DSP may be an important factor in dentinogenesis. DPP may bind high amount of calcium and facilitate initial mineralization of dentin matrix collagen as well as regulate the size and shape of the crystals.
See full target information DSPP
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Molecular therapy. Nucleic acids 25:116-126 PubMed34401209

2021

lncRNA H19 facilitates the proliferation and differentiation of human dental pulp stem cells via EZH2-dependent LATS1 methylation.

Applications

Unspecified application

Species

Unspecified reactive species

Zhen Du,Xiaoming Shi,Aizhong Guan
View all publications
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