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AB117493

DyLight® 488 Anti-Hemagglutinin antibody

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(1 Publication)

Rabbit Polyclonal Hemagglutinin antibody - conjugated to DyLight® 488. Suitable for ICC/IF and reacts with Influenza A samples. Cited in 1 publication.

View Alternative Names

HA, HA2

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Conjugation

DyLight® 488

Excitation/Emission

Ex: 493nm, Em: 518nm

Carrier free

No

Reacts with

Influenza A

Applications

ICC/IF

applications

Specificity

This antibody will recognize H3N2 subtype.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Influenza A": { "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: 1.6% Sodium phosphate, 1% BSA, 0.88% Sodium chloride
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Hemagglutinin also known as HA is a protein with a mass of approximately 70 kDa. This surface protein expresses mainly on the envelope of influenza viruses. Hemagglutinin plays an important role in binding the virus to host cell receptors and facilitates entry of viral particles into the target cells. The protein undergoes a conformational change to promote fusion between the viral envelope and host cell membranes which is essential for viral infectivity.
Biological function summary

Hemagglutinin mediates host immune recognition since it serves as a major antigenic component. The protein forms a trimeric complex with each subunit comprising two functional regions HA1 and HA2. HA1 is responsible for receptor binding while HA2 is involved in membrane fusion. The immunogenic nature of hemagglutinin challenges the immune system to produce antibodies targeting this structure making it a focus for vaccine design.

Pathways

Hemagglutinin directly interacts with the endocytosis pathway. This interaction facilitates the internalization of the virus into endosomes where the acidic environment triggers hemagglutinin-mediated fusion of viral and endosomal membranes. Hemagglutinin's function in these pathways closely relates to viral neuraminidase which aids in the release of progeny viruses from infected host cells after replication.

Hemagglutinin is notably central to influenza infection an acute respiratory condition with significant morbidity and mortality. Antigenic variations in hemagglutinin contribute to seasonal flu epidemics and potential pandemics. These variations also complicate vaccine formulation as antibodies generated against one hemagglutinin variant may be less effective against others. Additionally hemagglutinin maintains a relationship with the M2 ion channel protein which is important in viral uncoating and replication processes thereby influencing virus pathogenicity and disease outcomes.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information Hemagglutinin
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Cell 167:248-259.e12 PubMed27662092

2016

Portable, On-Demand Biomolecular Manufacturing.

Applications

Unspecified application

Species

Unspecified reactive species

Keith Pardee,Shimyn Slomovic,Peter Q Nguyen,Jeong Wook Lee,Nina Donghia,Devin Burrill,Tom Ferrante,Fern R McSorley,Yoshikazu Furuta,Andyna Vernet,Michael Lewandowski,Christopher N Boddy,Neel S Joshi,James J Collins
View all publications
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Primary Antibodies

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