AB117484

DyLight® 550 Anti-GST antibody

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(2 Publications)

Goat Polyclonal GST antibody - conjugated to DyLight® 550. Suitable for Flow Cyt and reacts with Tag samples. Cited in 2 publications.

View Alternative Names

Glutathione S-transferase class-mu 26 kDa isozyme, GST 26, Sj26 antigen, SjGST

1 Images

Flow Cytometry - DyLight® 550 Anti-GST antibody (AB117484)

Flow Cyt

Unknown

Flow Cytometry - DyLight® 550 Anti-GST antibody (AB117484)

Spectral Characteristic
Visible absorption maxima 562 nm
Emission maximum 576 nm

Key facts

Host species

Goat

Clonality

Polyclonal

Isotype

IgG

Conjugation

DyLight® 550

Excitation/Emission

Ex: 562nm, Em: 576nm

Carrier free

No

Applications

Flow Cyt

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Secondary Antibodies

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Tag": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "<p></p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein G

Storage buffer

pH: 7.4 Preservative: 0.02% Sodium azide Constituents: 1.6% Sodium phosphate, 1% BSA, 0.88% Sodium chloride

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

+4°C

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

GST or Glutathione S-transferase is an enzyme family known for detoxifying endogenous and exogenous compounds through conjugation with glutathione. GSTs are about 23–28 kDa in size and are expressed in various tissues such as the liver kidneys and lungs. The GST proteins play vital roles in cellular processes and are utilized extensively in molecular biology often tagged to proteins to enhance solubility known as GST-tagged proteins.

Biological function summary

GST enzymes participate in critical cellular detoxification processes enhancing the solubility of toxins. As part of these processes GST enzymes do not function as part of a larger complex but are individual actors within the cell. They facilitate the conjugation reactions fundamental to cellular metabolism and detoxification making them essential for maintaining cellular health.

Pathways

GST enzymes contribute significantly to the metabolic breakdown pathways like the xenobiotic metabolism pathway. This pathway involves proteins such as cytochrome P450 enzymes which often function upstream to modify compounds for further GST action. GSTs are important for efficiently detoxifying potentially harmful substances preventing cellular damage.

GSTs have considerable relevance to cancer where their overexpression can confer drug resistance in tumor cells complicating treatment approaches. Additionally these enzymes connect with proteins such as MDR1 influencing multidrug resistance in cancer therapy. GSTs also relate to asthma where altered GST activity can affect the body's response to oxidative stress highlighting the enzyme's role in inflammatory processes.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.. GST isoenzymes appear to play a central role in the parasite detoxification system. Other functions are also suspected including a role in increasing the solubility of haematin in the parasite gut.

See full target information Glutathione S-transferase class-mu 26 kDa isozyme

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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

International journal of pediatric otorhinolaryngo 127:109656 PubMed31470202

2019

Lipopolysaccharide disrupts the cochlear blood-labyrinth barrier by activating perivascular resident macrophages and up-regulating MMP-9.

Applications

Unspecified application

Species

Unspecified reactive species

Ying Jiang,Jie Zhang,Yufang Rao,Junhong Chen,Kai Chen,Yuedi Tang

Human molecular genetics 27:638-648 PubMed29293963

2018

Myostatin inhibition using mRK35 produces skeletal muscle growth and tubular aggregate formation in wild type and TgACTA1D286G nemaline myopathy mice.

Applications

Unspecified application

Species

Unspecified reactive species

Jennifer A Tinklenberg,Emily M Siebers,Margaret J Beatka,Hui Meng,Lin Yang,Zizhao Zhang,Jacob A Ross,Julien Ochala,Carl Morris,Jane M Owens,Nigel G Laing,Kristen J Nowak,Michael W Lawlor

View all publications

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Product promise

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