Anti-DYRK1A antibody - C-terminal

Target data

Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities (PubMed : 20981014, PubMed : 21127067, PubMed : 23665168, PubMed : 30773093, PubMed : 8769099). Exhibits a substrate preference for proline at position P+1 and arginine at position P-3 (PubMed : 23665168). Plays an important role in double-strand breaks (DSBs) repair following DNA damage (PubMed : 31024071). Mechanistically, phosphorylates RNF169 and increases its ability to block accumulation of TP53BP1 at the DSB sites thereby promoting homologous recombination repair (HRR) (PubMed : 30773093). Also acts as a positive regulator of transcription by acting as a CTD kinase that mediates phosphorylation of the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) POLR2A (PubMed : 25620562, PubMed : 29849146). May play a role in a signaling pathway regulating nuclear functions of cell proliferation (PubMed : 14500717). Modulates alternative splicing by phosphorylating the splice factor SRSF6 (By similarity). Has pro-survival function and negatively regulates the apoptotic process (By similarity). Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1 (By similarity). This in turn inhibits p53/TP53 activity and apoptosis (By similarity). Phosphorylates SEPTIN4, SEPTIN5 and SF3B1 at 'Thr-434' (By similarity).