JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB244440

Anti-Dystonin/BPA antibody

Be the first to review this product! Submit a review

|

(1 Publication)

Rabbit Polyclonal Dystonin/BPA antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human DST aa 2600 to C-terminus.

View Alternative Names

BP230, BP240, BPAG1, DMH, DT, KIAA0728, DST, Dystonin, 230 kDa bullous pemphigoid antigen, 230/240 kDa bullous pemphigoid antigen, Bullous pemphigoid antigen 1, Dystonia musculorum protein, Hemidesmosomal plaque protein, BPA, Bullous pemphigoid antigen

5 Images
Immunocytochemistry/ Immunofluorescence - Anti-Dystonin/BPA antibody (AB244440)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-Dystonin/BPA antibody (AB244440)

PFA-fixed, Triton X-100 permeabilized A431 (human epidermoid carcinoma cell line) cells stained for Dystonin/BPA (green) using ab244440 at 4 μg/ml in ICC/IF.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Dystonin/BPA antibody (AB244440)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Dystonin/BPA antibody (AB244440)

Formalin-fixed, paraffin-embedded human cerebellum tissue stained for Dystonin/BPA with ab244440 at a 1/50 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Dystonin/BPA antibody (AB244440)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Dystonin/BPA antibody (AB244440)

Formalin-fixed, paraffin-embedded human prostate tissue stained for Dystonin/BPA with ab244440 at a 1/50 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Dystonin/BPA antibody (AB244440)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Dystonin/BPA antibody (AB244440)

Formalin-fixed, paraffin-embedded human kidney tissue stained for Dystonin/BPA with ab244440 at a 1/50 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Dystonin/BPA antibody (AB244440)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Dystonin/BPA antibody (AB244440)

Formalin-fixed, paraffin-embedded human tonsil tissue stained for Dystonin/BPA with ab244440 at a 1/50 dilution in immunohistochemical analysis.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human DST aa 2600 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q03001

style
left-column

Alternative Products

Primary Antibodies

AB234644

Anti-Dystonin/BPA antibody

Immunocytochemistry/ Immunofluorescence - Anti-Dystonin/BPA antibody (AB234644)

  • 0
  • 0

Complementary Products

Primary Antibodies

AB184996

Anti-Collagen XVII antibody [EPR18614]

20ul selling size|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Collagen XVII antibody [EPR18614] (AB184996)

  • 5
  • 4
Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Primary Antibodies

AB15580

Anti-Ki67 antibody

BOND RX™ Validated|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Ki67 antibody (AB15580)

  • 5
  • 230
Primary Antibodies

AB124798

Anti-Desmoglein 1/DSG1 antibody [EPR6766(B)]

RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Desmoglein 1/DSG1 antibody [EPR6766(B)] (AB124798)

  • 5
  • 5
style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100.</p>" } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Dystonin also known as BPA (Bullous Pemphigoid Antigen) is a large protein with a molecular mass of approximately 800 kDa. This versatile protein plays a mechanical role by providing structural integrity to cells particularly within tissues that experience mechanical stress. Dystonin locates mainly in the cytoskeleton-associated regions of muscle and neural cells where it connects cytoskeletal components to membrane complexes. The presence of dystonin in these areas indicates its function in maintaining tissue cohesion and stability under stress.
Biological function summary

Dystonin acts as a cytoskeletal linker that maintains cellular architecture by directly linking intermediate filaments to the actin and microtubule networks. As part of this structural network dystonin forms complexes with other proteins to stabilize cell junctions and muscle fibers. In neural tissues it plays an important role in maintaining the integrity of axons essential for proper nerve function. Dystonin ensures cells retain their shape and positioning which is necessary for regular cellular functions and signal transmissions in these tissues.

Pathways

Dystonin interacts with multiple structural proteins in the cytoskeletal pathway such as keratins and microtubule-associated proteins. The linkage function of dystonin integrates it into the hemidesmosomal pathway which is vital for epithelial cell adhesion. Dystonin works along with other proteins like integrins and plectin which also engage in these pathways promoting cellular adhesion and resilience against mechanical stress.

Mutations or deficiencies in dystonin link to diseases like bullous pemphigoid and Hereditary Sensory and Autonomic Neuropathy Type VI (HSAN VI). Bullous pemphigoid is an autoimmune disorder characterized by blistering of the skin due to compromised cell adhesion. The lack of functional dystonin in HSAN VI leads to nerve degradation highlighting its role in neural maintenance. Proteins like integrins are also implicated in these conditions emphasizing the importance of dystonin-related pathways in maintaining cell adhesion and nerve integrity.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

Cytoskeletal linker protein. Acts as an integrator of intermediate filaments, actin and microtubule cytoskeleton networks. Required for anchoring either intermediate filaments to the actin cytoskeleton in neural and muscle cells or keratin-containing intermediate filaments to hemidesmosomes in epithelial cells. The proteins may self-aggregate to form filaments or a two-dimensional mesh. Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. Mediates docking of the dynein/dynactin motor complex to vesicle cargos for retrograde axonal transport through its interaction with TMEM108 and DCTN1 (By similarity).. Isoform 3. Plays a structural role in the assembly of hemidesmosomes of epithelial cells; anchors keratin-containing intermediate filaments to the inner plaque of hemidesmosomes. Required for the regulation of keratinocyte polarity and motility; mediates integrin ITGB4 regulation of RAC1 activity.. Isoform 6. Required for bundling actin filaments around the nucleus.. Isoform 7. Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport.
See full target information DST
style
left-column

Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Theranostics 15:6516-6533 PubMed40521210

2025

Loss of in Pancreatic Adenocarcinoma Reversed the Tumor-Promoting Effects of a High-Fat Diet.

Applications

Unspecified application

Species

Unspecified reactive species

Sang Myung Woo,Ho Lee,Joon Hee Kang,Mingyu Kang,Wonyoung Choi,Sung Hoon Sim,Jung Won Chun,Nayoung Han,Kyung-Hee Kim,Woojin Ham,Woosol Hong,Chaeyoung Kim,Jeong Hwan Park,Dawool Han,Jong In Yook,Woo Jin Lee,Soo-Youl Kim
View all publications
style
left-column
style
left-column
style
right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com