Anti-E2F1 antibody

• WB

CiteAb

Western blot - Anti-E2F1 antibody (AB137415)

E2F1 western blot using anti-E2F1 antibody ab137415. Publication image and figure legend from Wu, C. C., Jin, L. W., et al., 2020, EMBO Mol Med, PubMed 32449313.

ab137415 was used in this publication in western blot. This may not be the same as the application(s) guaranteed by Abcam. For a full list of applications guaranteed by Abcam for ab137415 please see the product overview.

Aberrant cell cycle activity correlates with TDP-43 proteinopathies in FTLD-TDP Tg miceARepresentative immunofluorescence (IF) staining of Ki67 and TDP-43 in the regions of frontal cortices from 6-mon-old WT and FTLD-TDP Tg mice. Nuclei were stained with 4',6-diamidino-2-phenylindole (DAPI; upper panel in blue) or neural marker NeuN (lower panel in green). Scale bar : 50 μm. The circled area is emphasized for showing the distribution of immunoreactivity in cell subregions. Scale bar : 15 μm.BQuantification of cells or neurons with Ki67 immunoreactivity and TDP-43 mislocalization from each view of microscope. n = 9 sections per mouse, N = 5 mice per group, data are presented as mean ± SEM, ***P = 0.0007 by t-test.CRepresentative data of reverse transcription PCR (left panel) or Western blot (right panel) for cell cycle-related genes and semi-quantification of the expression levels in the frontal cortices and hippocampus from the 6-mon-old WT and FTLD-TDP Tg mice. N = 5 mice per group, data are presented as mean ± SEM (%), statistical analysis by multiple t-test with FDR correction, Q = 1%. *p < 0.05, **P ≤ 0.01; ***P ≤ 0.001 and ****P ≤ 0.0001, exact P values are shown in Appendix Table S1.Source data are available online for this figure.

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