Anti-E2F2 antibody [2302C4a]

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Biological function summary

E2F2 functions as a transcriptional activator and repressor controlling genes necessary for DNA synthesis and cell cycle progression. It often associates with retinoblastoma protein (RB1) to form complexes that finely regulate gene transcription. E2F2 not only controls cell proliferation but also influences cell differentiation processes by coordinating the balance between distinct cellular states.

Pathways

E2F2 interacts with key players in the cell cycle such as cyclins and cyclin-dependent kinases (CDKs). It is an integral part of the Rb-E2F signaling pathway which governs cell cycle checkpoints and progression. This pathway's regulation heavily influences the activities of other E2F family members such as E2F1 and E2F3 which can either promote or inhibit cell cycle transitions in response to various signals.