Anti-EAAT5 antibody

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Biological function summary

EAAT5 mediates glutamatergic neurotransmission by removing excess glutamate from the synaptic cleft reducing excitotoxicity and maintaining synaptic plasticity. The function of EAAT5 is critical in visual processing as it plays a role in signal transmission in the retina. It operates as part of a complex that involves various neurotransmitter transporters and channels ensuring precise communication between photoreceptor cells and downstream neurons. The transport activity of EAAT5 impacts neurotransmitter gradients influencing visual perception and adaptation to light changes.

Pathways

EAAT5 participates in the glutamatergic signaling pathway where it helps modulate synaptic transmission by controlling extracellular glutamate levels. It is functionally related to other members of the excitatory amino acid transporter family such as EAAT1 and EAAT2 which also manage glutamate reuptake in the central nervous system. The protein's interplay in the regulation of glutamate impacts neural activities and is associated with the Catabolism of Glutamate pathway. These transporters work together to ensure glutamate does not accumulate to toxic levels safeguarding neurons from damage.