Anti-EAF2 antibody [EPR7117(2)] - BSA and Azide free

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

EAF2 also known as ELL-associated factor 2 plays an important role in transcription regulation. This protein weighing approximately 32 kDa interacts with the ELL (eleven-nineteen lysine-rich leukemia) family of RNA polymerase II elongation factors. EAF2 expression is noted in various tissues including the prostate colon and liver indicating a broad impact on cellular functions across the body. Researchers often study EAF2 for its regulatory abilities and its influence on gene expression.

Biological function summary

EAF2 regulates the transcription elongation process. It works as part of a complex with ELL proteins impacting the rate at which RNA polymerase II can transcribe genetic information into messenger RNA. The EAF2-ELL complex stabilizes and enhances the transcription process ensuring proper gene expression and cellular function. Its influence on transcription shapes how cells respond to their environment making EAF2 a protein of interest in many studies.

Pathways

EAF2 significantly impacts the androgen receptor signaling pathway and transcriptional regulation pathways. In the androgen receptor pathway EAF2 influences gene expression by modulating the activity of this receptor affecting processes such as cell growth and differentiation. Furthermore it interacts with other proteins within these pathways including androgen receptor itself and transcriptional machinery components like RNA polymerase II linking it to cellular proliferation and hormone response.

Associated diseases and disorders

EAF2 has a connection to prostate cancer and chronic liver disease. Its role in prostate cancer stems from its involvement in androgen receptor pathways where aberrant expression or dysfunction might contribute to tumor development and progression. EAF2 interacts with other proteins like ELL and androgen receptors making it a potential target for cancer therapy. In chronic liver disease understanding EAF2's contributions to transcription regulation might reveal its role in liver physiology and pathology providing insights into disease mechanisms and potential treatment strategies.