AB108537

Anti-EAG1 antibody [EPR3802]

RabMAb
Recombinant
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(1 Publication)

Rabbit Recombinant Monoclonal EAG1 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication.

View Alternative Names

EAG, EAG1, KCNH1, Voltage-gated delayed rectifier potassium channel KCNH1, Ether-a-go-go potassium channel 1, Potassium voltage-gated channel subfamily H member 1, Voltage-gated potassium channel subunit Kv10.1, EAG channel 1, h-eag, hEAG1

1 Images

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Western blot - Anti-EAG1 antibody [EPR3802] (AB108537)

All lanes:

Western blot - Anti-EAG1 antibody [EPR3802] (ab108537) at 1/1000 dilution

Lane 1:

SH-SY5Y cell lysate at 10 µg

Lane 2:

MCF7 cell lysate at 10 µg

Lane 3:

A673 cell lysate at 10 µg

Predicted band size: 111 kDa

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Carrier free

Anti-EAG1 antibody [EPR3802] - BSA and Azide free

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR3802

Isotype

IgG

Carrier free

Reacts with

Human

Applications

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

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Product details

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form

Liquid

Purity

Tissue culture supernatant

Storage buffer

pH: 7.2 - 7.4 Preservative: 0.05% Sodium azide Constituents: 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 9.85% Tris glycine, 0.1% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Storage information

Stable for 12 months at -20°C

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

EAG1 also known as Kv10.1 is a voltage-gated potassium channel with a molecular mass approximately 110 kDa. This protein plays a critical role in regulating membrane potential by allowing potassium ions to flow in response to voltage changes across the cell membrane. EAG1 is prominently expressed in the brain with presence noted in other tissues such as the heart and peripheral nervous system. Its activity influences the electrical excitability of neurons and has implications in cellular signaling.

Biological function summary

EAG1 is involved in key processes governing cellular excitability and proliferation. The channel contributes to setting the electrical properties of cells especially in neurons by controlling action potential dynamics. EAG1 does not typically form part of a complex but it can interact with other membrane proteins or signaling molecules modulating its activity. In certain contexts its aberrant expression can lead to altered cellular behaviors linking it to various cellular functional states.

Pathways

EAG1 engages in the regulation of the MAPK signaling pathway and is also significant in the PI3K/AKT pathway. These pathways are important for transmitting cellular signals that influence cell growth and survival. In the context of the MAPK pathway EAG1’s activity may interact with proteins such as B-Raf affecting downstream signaling events. Similarly in the PI3K/AKT pathway interactions can occur with proteins like AKT further integrating EAG1 within these essential frameworks.

EAG1 shows a connection to cancer and epilepsy. EAG1 overexpression has been documented in various cancers including breast and colon cancers where it may drive tumorigenic processes through its influence on cell proliferation and survival pathways. Moreover aberrant EAG1 function links to epilepsy potentially through its impact on neuronal excitability and neurotransmission. In these conditions EAG1 may interact with proteins such as p53 in cancer altering cell cycle control or with neurotransmitter receptors in epilepsy impacting neuronal networks.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Pore-forming (alpha) subunit of a voltage-gated delayed rectifier potassium channel that mediates outward-rectifying potassium currents which, on depolarization, reaches a steady-state level and do not inactivate (PubMed : 10880439, PubMed : 11943152, PubMed : 22732247, PubMed : 25420144, PubMed : 25556795, PubMed : 25915598, PubMed : 27005320, PubMed : 27325704, PubMed : 27618660, PubMed : 30149017, PubMed : 9738473). The activation kinetics depend on the prepulse potential and external divalent cation concentration (PubMed : 11943152). With negative prepulses, the current activation is delayed and slowed down several fold, whereas more positive prepulses speed up activation (PubMed : 11943152). The time course of activation is biphasic with a fast and a slowly activating current component (PubMed : 11943152). Activates at more positive membrane potentials and exhibit a steeper activation curve (PubMed : 11943152). Channel properties are modulated by subunit assembly (PubMed : 11943152). Mediates IK(NI) current in myoblasts (PubMed : 9738473). Involved in the regulation of cell proliferation and differentiation, in particular adipogenic and osteogenic differentiation in bone marrow-derived mesenchymal stem cells (MSCs) (PubMed : 23881642).

See full target information KCNH1

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Scientific reports 15:29297 PubMed40789880

2025

Mannose-B from Codonopsis pilosula modulates LAMB1 expression to enhance trophoblast function and alleviate subchorionic hematoma.

Applications

Unspecified application

Species

Unspecified reactive species

Qian Sun,Yuan Gao,Kadirya Asan,Jing Ji,Jinjin Xu,Xiaoyan Wu,Jie Ren,Wen Feng,Mengwei Song,Sen Wang,Boyu Zhang,Ying Zhou,Conghui Han,Shun Liu,Wen Yang

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-EAG1 antibody [EPR3802]

Western blot - Anti-EAG1 antibody [EPR3802] (AB108537)

Related conjugates and formulations (1)

Key facts

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Product details

Properties and storage information

Form

Purity

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (1)

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