Rabbit Polyclonal EAG2 antibody. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human KCNH5 aa 350-450.
Images
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: PBS, 40% Glycerol (glycerin, glycerine)- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Recombinant Fragment Protein within Human KCNH5 aa 350-450. The exact immunogen used to generate this antibody is proprietary information. Database link Q8NCM2
Reactivity data
Select an application| IHC-P | |
|---|---|
| Human | Tested |
| Mouse | Predicted |
| Rat | Predicted |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/50.00000 - 1/200.00000 | Notes Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Rat | Dilution info - | Notes - |
Target data
Function
Pore-forming (alpha) subunit of a voltage-gated delayed rectifier potassium channel that mediates outward-rectifying potassium currents which, on depolarization, reaches a steady-state level and do not inactivate (PubMed:11943152, PubMed:12135768, PubMed:24133262, PubMed:36928654). The kinetic is characterized by a slow activation time course and a small voltage dependence of the activation time constants, therefore, starts to open at more negative voltages (PubMed:11943152, PubMed:12135768). The activation kinetics depend on the prepulse potential and external divalent cation concentration (PubMed:11943152, PubMed:24133262). The time course of activation is biphasic with a fast and a slowly activating current component (PubMed:11943152, PubMed:12135768, PubMed:36928654). With negative prepulses, the current activation is delayed and slowed down several fold, whereas more positive prepulses speed up activation, therefore the activation rate depends on holding potential (PubMed:11943152, PubMed:12135768, PubMed:36928654).
Alternative names
EAG2, KCNH5, Voltage-gated delayed rectifier potassium channel KCNH5, Ether-a-go-go potassium channel 2, Potassium voltage-gated channel subfamily H member 5, Voltage-gated potassium channel subunit Kv10.2, hEAG2
Recommended products
Rabbit Polyclonal EAG2 antibody. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human KCNH5 aa 350-450.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: PBS, 40% Glycerol (glycerin, glycerine)- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Recombinant Fragment Protein within Human KCNH5 aa 350-450. The exact immunogen used to generate this antibody is proprietary information. Database link Q8NCM2
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
EAG2 also known as Kv10.2 or KCNH5 is a voltage-gated potassium channel protein. It possesses a molecular mass of approximately 107 kDa. This protein plays a significant role in the regulation of membrane potential by allowing potassium ions to pass through cell membranes. EAG2 is expressed mainly in the central nervous system including the brain and spinal cord. It facilitates the modulation of electrical signals in neurons which is essential for various neural functions.
- Biological function summary
EAG2 contributes to the maintenance of neuronal excitability and action potential timing. It functions as part of a larger ion channel complex that includes other potassium channels. These complexes help fine-tune the electrical activity of neurons important for proper signaling and communication within the brain. The proper functioning of EAG2 is necessary for maintaining normal neurophysiological processes.
- Pathways
EAG2 integrates into cellular signaling pathways such as the MAPK and calcium signaling pathways which are important for neuronal growth and plasticity. It interacts with proteins like Ca2+ channels influencing calcium influx in neurons. In this context EAG2 indirectly affects dopamine signaling and synaptic transmission which are vital for cognitive and motor functions.
- Associated diseases and disorders
EAG2 has been associated with neurological and psychiatric disorders including schizophrenia and epilepsy. There is evidence suggesting that dysregulation of EAG2 can disturb normal neuronal signaling leading to these conditions. Additionally the protein may interact with SK channels in the context of these disorders further disrupting normal ion flow and electrical activity in affected neurons.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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1 product image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-EAG2 antibody (ab224482)
Paraffin-embedded human prostate stained for EAG2 using ab224482 at 1/50 dilution in immunohistochemical analysis.
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