AB16126

Anti-EBNA 3A antibody

Name: Anti-EBNA 3A antibody (ab16126) | Abcam
Brand: Abcam Limited
SKU: AB16126
Price: 535 USD
Availability: InStock
Rating: 4 (1 reviews)

(1 Review)

(16 Publications)

Sheep Polyclonal EBNA3 antibody. Suitable for WB, ICC, Dot, ELISA, IHC-Fr and reacts with Epstein-Barr virus samples. Cited in 16 publications.

View Alternative Names

EBV, Epstein Barr virus, HHV4, Nuclear antigen EBNA 3A

1 Images

Supplier Data

Western blot - Anti-EBNA 3A antibody (AB16126)

All lanes:

Western blot - Anti-EBNA 3A antibody (ab16126)

All lanes:

Cell line infected with Epstein Barr virus.

Predicted band size: 102 kDa

false

Key facts

Host species

Sheep

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Epstein-Barr virus

Applications

WB, Dot, IHC-Fr, ELISA, ICC

applications

Specificity

This antibody is specific for the Epstein Barr Virus Nuclear Antigen 3A.

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Reactivity data

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Product details

Sheep were immunized with recombinant EBNA-3A protein

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Properties and storage information

Form

Liquid

Purification technique

Precipitation Ammonium Sulphate

Purification notes

Purified by ammonium sulfate precipitation.This antibody is provided as a 0.2µm sterile filtered solution.

Storage buffer

Preservative: 0.08% Sodium azide Constituents: PBS

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

EBNA 3A also known as Epstein-Barr Nuclear Antigen 3A is a protein associated with the Epstein-Barr virus (EBV). This protein has a mass of approximately 115 kDa and is expressed in host cells infected with EBV. EBNA 3A functions as a transcriptional regulator by interacting with DNA and modulating gene expression. EBNA 3A is critical for viral latency and is expressed within the nuclei of infected B lymphocytes contributing to the persistence of the virus within host cells.

Biological function summary

EBNA 3A modulates the host cell cycle and contributes to the immortalization of infected B cells. EBNA 3A EBNA 3B and EBNA 3C form a complex that regulates viral and cellular genes. This complex plays roles in transcriptional repression and activation affecting cell growth and transformation. Through these mechanisms EBNA 3A influences immune evasion by the virus as EBV can maintain a state of latency and avoid detection by the host immune system.

Pathways

EBNA 3A participates in the regulation of the cell cycle and immune signaling. EBNA 3A affects pathways such as the Notch signaling pathway and can alter interactions with proteins like RBP-Jκ. These pathways are important for the control of gene expression and cell differentiation in infected cells. By influencing these pathways EBNA 3A helps EBV manipulate host cell behaviors to support viral replication and persistence.

EBNA 3A is linked to conditions like Burkitt's lymphoma and Hodgkin's lymphoma. These cancers are associated with the transformation of B cells resulting from EBV infection and EBNA 3A collaborates with other viral proteins such as EBNA-LP to contribute to the oncogenic processes. The presence and activity of EBNA 3A in these lymphomas suggest that targeting this protein could offer potential therapeutic avenues for managing EBV-related malignancies.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

See full target information EBNA 3A

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Publications (16)

Recent publications for all applications. Explore the full list and refine your search

PLoS pathogens 21:e1013410 PubMed40773523

2025

E2F1 suppresses Epstein-Barr virus lytic reactivation through cellular and viral transcriptional networks.

Applications

Unspecified application

Species

Unspecified reactive species

Joyanta Biswas,Sk Asif Ali,Samaresh Malik,Subhadeep Nag,Piyali Mukherjee,Abhik Saha

PLoS pathogens 20:e1011998 PubMed38530845

2024

Differential carbonic anhydrase activities control EBV-induced B-cell transformation and lytic cycle reactivation.

Applications

Unspecified application

Species

Unspecified reactive species

Samaresh Malik,Joyanta Biswas,Purandar Sarkar,Subhadeep Nag,Chandrima Gain,Shatadru Ghosh Roy,Bireswar Bhattacharya,Dipanjan Ghosh,Abhik Saha

Translational oncology 40:101831 PubMed38039947

2023

Silencing of PD-1 combined with EBV-specific killer T cells for the treatment of EBV-associated B lymphoma.

Applications

Unspecified application

Species

Unspecified reactive species

Jiaping Wang,Zhijuan Xu,Yanli Lai,Yanli Zhang,Ping Zhang,Qitian Mu,Shujun Yang,Yongcheng Sun,Lixia Sheng,Guifang Ouyang

Life science alliance 6: PubMed36878637

2023

Endemic Burkitt lymphoma avatar mouse models for exploring inter-patient tumor variation and testing targeted therapies.

Applications

Unspecified application

Species

Unspecified reactive species

Priya Saikumar Lakshmi,Cliff I Oduor,Catherine S Forconi,Viriato M'Bana,Courtney Bly,Rachel M Gerstein,Juliana A Otieno,John M Ong'echa,Christian Münz,Micah A Luftig,Michael A Brehm,Jeffrey A Bailey,Ann M Moormann

Autophagy 19:678-691 PubMed35838483

2022

Autophagy-associated immune dysregulation and hyperplasia in a patient with compound heterozygous mutations in .

Applications

Unspecified application

Species

Unspecified reactive species

Guowu Hu,Pia J Hauk,Nannan Zhang,Waleed Elsegeiny,Carlos M Guardia,Amy Kullas,Kevin Crosby,Robin R Deterding,Michaela Schedel,Paul Reynolds,Jordan K Abbott,Vijaya Knight,Stefania Pittaluga,Mark Raffeld,Sergio D Rosenzweig,Juan S Bonifacino,Gulbu Uzel,Peter R Williamson,Erwin W Gelfand

Anticancer research 40:5951-5968 PubMed33109533

2020

EBV Positivity and Programmed Death-ligand 1 Expression in Diffuse Large B-cell Lymphoma: A Systematic Review.

Applications

Unspecified application

Species

Unspecified reactive species

Gabriela Anna Barzyk,Vafie Sheriff

PLoS pathogens 16:e1008105 PubMed32092124

2020

Proteasomal inhibition triggers viral oncoprotein degradation via autophagy-lysosomal pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Chandrima Gain,Samaresh Malik,Shaoni Bhattacharjee,Arijit Ghosh,Erle S Robertson,Benu Brata Das,Abhik Saha

Nucleic acids research 47:2807-2821 PubMed30649516

2019

Requirement for PRC1 subunit BMI1 in host gene activation by Epstein-Barr virus protein EBNA3C.

Applications

Unspecified application

Species

Unspecified reactive species

Kostas Paschos,Quentin Bazot,Jonathan Lees,Paul J Farrell,Martin J Allday

Journal of virology 92: PubMed30135119

2018

Epstein-Barr Virus Nuclear Antigen 3C Inhibits Expression of and the Locus via Interaction with the Histone Lysine Demethylase KDM2B.

Applications

Unspecified application

Species

Unspecified reactive species

Adam C T Gillman,Gillian Parker,Martin J Allday,Quentin Bazot

Journal of virology 92: PubMed29367247

2018

Epstein-Barr Virus (EBV) Latent Protein EBNA3A Directly Targets and Silences the Gene in B Cells Infected by EBV.

Applications

Unspecified application

Species

Unspecified reactive species

Quentin Bazot,Kostas Paschos,Martin J Allday

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-EBNA 3A antibody

Western blot - Anti-EBNA 3A antibody (AB16126)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Specificity

Reactivity data

Product details

Properties and storage information

Form

Purification technique

Purification notes

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (16)

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