JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB243283

Anti-Ebola virus antibody

Be the first to review this product! Submit a review

|

(0 Publication)

Sheep Polyclonal Ebola virus antibody. Carrier free. Suitable for WB and reacts with Zaire ebolavirus samples.
1 Images
Western blot - Anti-Ebola virus antibody (AB243283)
  • WB

Supplier Data

Western blot - Anti-Ebola virus antibody (AB243283)

Western blot - Anti-Envelope Glycoprotein antibody (ab243283)

All lanes:

Western blot - Anti-Ebola virus antibody (ab243283)

false

Key facts

Host species

Sheep

Clonality

Polyclonal

Isotype

IgG

Carrier free

Yes

Reacts with

Zaire ebolavirus

Applications

WB

applications

Specificity

This antibody is specific for the Zaire ebola virus matrix protein (VP40), nucleoprotein (NP) and glycoprotein (GP). The antibody has not been tested on other filovirus proteins.

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Zaire ebolavirus": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/2500", "WB-species-notes": "<p></p>" } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Storage buffer
pH: 7 - 8 Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Ebola virus also known as Ebola Zaire is responsible for causing severe hemorrhagic fever in humans and nonhuman primates. The virion of the Ebola virus is filamentous and has a mass of approximately 19 kb. It is primarily expressed in the host's vascular tissue liver and immune system targeting various cell types including monocytes macrophages and dendritic cells. When the virus enters cells it hijacks the host's machinery to replicate its genetic material and produce viral proteins facilitating the assembly of new viral particles.
Biological function summary

The virus disrupts regular immune responses and inflammatory pathways leading to a systemic infection. The virus forms part of a complex involving several of its own proteins such as the glycoprotein (GP) which plays an important role in cell entry and immune evasion. By modifying surface structures of host cells the virus can bind and internalize ultimately leading to cellular destruction and organ failure.

Pathways

Ebola virus interferes with both innate and adaptive immune response pathways. It disrupts the interferon signaling pathway to evade immune detection leading to uncontrolled viral replication. The virus also affects pathways related to apoptosis and inflammation through interactions with host proteins like TLRs (Toll-like receptors) and signaling intermediates which promote an excessive inflammatory response causing further tissue damage.

Ebola virus is directly linked to Ebola virus disease (EVD) and can potentially contribute to systemic inflammatory response syndrome. The virus's interaction with several host proteins such as the TLRs and cytokines results in dysregulated immune responses which are significant in the progression of EVD. The rapid and aggressive nature of the infection highlights the necessity of targeting proteins like GP with Ebola antibodies to control viral spread and improve patient outcomes.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

See full target information Ebola virus
style
left-column
style
left-column
style
right-column

Complementary Products

Primary Antibodies

AB99316

Anti-WRNIP1/WHIP antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-WRNIP1/WHIP antibody (AB99316)

  • 5
  • 1
Primary Antibodies

AB176689

Anti-ZNF384 antibody

Immunoprecipitation - Anti-ZNF384 antibody (AB176689)

  • 5
  • 1
Primary Antibodies

AB14734

Anti-VDAC1/Porin + VDAC3 antibody [20B12AF2] - Mitochondrial Loading Control

Recombinant|Lab Essentials

Western blot - Anti-VDAC1/Porin + VDAC3 antibody [20B12AF2] - Mitochondrial Loading Control (AB14734)

  • 5
  • 52
Proteins & Peptides

AB7403

Streptavidin (HRP)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Streptavidin (HRP) (AB7403)

  • 5
  • 7

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com