Anti-Ebola virus antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

Ebola virus also known as Ebola Zaire is responsible for causing severe hemorrhagic fever in humans and nonhuman primates. The virion of the Ebola virus is filamentous and has a mass of approximately 19 kb. It is primarily expressed in the host's vascular tissue liver and immune system targeting various cell types including monocytes macrophages and dendritic cells. When the virus enters cells it hijacks the host's machinery to replicate its genetic material and produce viral proteins facilitating the assembly of new viral particles.

Biological function summary

The virus disrupts regular immune responses and inflammatory pathways leading to a systemic infection. The virus forms part of a complex involving several of its own proteins such as the glycoprotein (GP) which plays an important role in cell entry and immune evasion. By modifying surface structures of host cells the virus can bind and internalize ultimately leading to cellular destruction and organ failure.

Pathways

Ebola virus interferes with both innate and adaptive immune response pathways. It disrupts the interferon signaling pathway to evade immune detection leading to uncontrolled viral replication. The virus also affects pathways related to apoptosis and inflammation through interactions with host proteins like TLRs (Toll-like receptors) and signaling intermediates which promote an excessive inflammatory response causing further tissue damage.

Associated diseases and disorders

Ebola virus is directly linked to Ebola virus disease (EVD) and can potentially contribute to systemic inflammatory response syndrome. The virus's interaction with several host proteins such as the TLRs and cytokines results in dysregulated immune responses which are significant in the progression of EVD. The rapid and aggressive nature of the infection highlights the necessity of targeting proteins like GP with Ebola antibodies to control viral spread and improve patient outcomes.