Anti-EBV Latent Membrane Protein 1 antibody [D24-G]

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Biological function summary

The protein plays a role in cellular transformation and proliferation acting as a mimic of CD40 receptor signaling. Within cells LMP1 aggregates to form oligomeric complexes that actively recruit TRAF and TRADD adapter proteins. This aggregation leads to the activation of NF-κB signaling and the MAPK pathways contributing to increased cell survival and proliferation. LMP1 functions as a major factor in sustaining EBV latency in infected cells and is essential for the virus's oncogenic potential.

Pathways

LMP1 is an integral component of the NF-κB and AP-1 signaling pathways. By engaging with the host cell machinery LMP1 recruits proteins such as IκB kinase complexes leading to the nuclear translocation of NF-κB transcription factors. This results in the transcription of genes related to cell growth and inflammation. LMP1 also interacts with p38 MAPK further enhancing pathways that contribute to EBV’s ability to foster an environment suitable for its persistence and propagation within the host.