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AB228490

Anti-ECEL1 antibody

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(2 Publications)

Rabbit Polyclonal ECEL1 antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ECEL1.

View Alternative Names

XCE, UNQ2431/PRO4991, ECEL1, Endothelin-converting enzyme-like 1, Xce protein

1 Images
Western blot - Anti-ECEL1 antibody (AB228490)
  • WB

Supplier Data

Western blot - Anti-ECEL1 antibody (AB228490)

7.5% SDS-PAGE

All lanes:

Western blot - Anti-ECEL1 antibody (ab228490) at 1/1000 dilution

Lane 1:

Non-transfected HEK-293T (human epithelial cell line from embryonic kidney transformed with large T antigen) cell lysate

Lane 2:

ECEL1-transfected HEK-293T cell lysate

Predicted band size: 88 kDa

true

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Human ECEL1. The exact immunogen used to generate this antibody is proprietary information.

O95672

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Secondary Antibodies

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ECEL1 also known as endothelin-converting enzyme-like 1 or puromycin-sensitive aminopeptidase is a zinc-dependent metalloprotease with a molecular mass of about 85 kDa. This enzyme primarily expresses in the nervous system indicating a unique role in neuronal function. ECEL1 localizes in the endoplasmic reticulum and Golgi apparatus participating in processing neuropeptides although its full range of substrates is not completely defined.
Biological function summary

ECEL1 functions to modulate neuropeptide activity by cleaving specific peptide bonds acting as a critical regulator in the nervous system. It does not appear to form part of a larger protein complex but interacts closely with other enzymes involved in neuropeptide processing. Through its enzymatic activity ECEL1 plays a role in maintaining neurotransmitter balance thereby influencing nervous system communication.

Pathways

ECEL1 participates in neuropeptide and signaling pathways such as the endothelin-signaling pathway. ECEL1's activity impacts the function and expression of proteins like endothelin and other neuropeptides involved in vasoconstriction and neurotransmission. ECEL1 works alongside enzymes like neprilysin cooperating in peptide degradation and activation processes within these pathways.

ECEL1 has association with musculoskeletal and neurological conditions including congenital contractural arachnodactyly. Mutations in ECEL1 can lead to disruptions in neuropeptide processing contributing to developmental abnormalities. Moreover studies suggest an involvement of ECEL1 with proteins such as those related to collagen metabolism linking it to connective tissue disorders and highlighting its role in proper muscular and neuronal development.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

May contribute to the degradation of peptide hormones and be involved in the inactivation of neuronal peptides.
See full target information ECEL1
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

CNS neuroscience & therapeutics 31:e70578 PubMed40904192

2025

Endothelin-Converting Enzyme-Like 1 Regulated by LIF Contributes to Chronic Constriction Injury-Induced Neuropathic Pain in Mice.

Applications

Unspecified application

Species

Unspecified reactive species

Feng Gao,Yuchen Pan,Yong Huang,Chen Gu,Xiaowei Song,Cunjin Wang

Proceedings of the National Academy of Sciences of the United States of America 120:e2304288120 PubMed37844244

2023

Defined extracellular matrix compositions support stiffness-insensitive cell spreading and adhesion signaling.

Applications

Unspecified application

Species

Unspecified reactive species

James R W Conway,Aleksi Isomursu,Gautier Follain,Ville Härmä,Eva Jou-Ollé,Nicolas Pasquier,Eetu P O Välimäki,Juha K Rantala,Johanna Ivaska
View all publications
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Product promise

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