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AB244451

Anti-ECM antibody

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(1 Publication)

Rabbit Polyclonal ECM antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human MMRN1 aa 650 to C-terminus.

View Alternative Names

ECM, EMILIN4, GPIA*, MMRN, MMRN1, Multimerin-1, EMILIN-4, Elastin microfibril interface located protein 4, Endothelial cell multimerin, Elastin microfibril interfacer 4

3 Images
Immunocytochemistry/ Immunofluorescence - Anti-ECM antibody (AB244451)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-ECM antibody (AB244451)

PFA-fixed, Triton X-100 permeabilized HUVEC TERT2 cells stained for ECM (green) using ab244451 at 4 μg/ml in ICC/IF.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ECM antibody (AB244451)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ECM antibody (AB244451)

Paraffin-embedded human gallbladder tissue stained for ECM using ab244451 at 1/500 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ECM antibody (AB244451)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ECM antibody (AB244451)

Paraffin-embedded human skeletal muscle tissue stained for ECM using ab244451 at 1/500 dilution in immunohistochemical analysis.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human MMRN1 aa 650 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q13201

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/500 - 1/1000", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100.</p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The extracellular matrix (ECM) constitutes a complex network of macromolecules such as proteins and glycoproteins including the key structural proteins like collagen elastin fibronectin and laminin. It provides structural support to cells and tissues and plays a role in signal transmission across the cellular environment. The ECM does not have a singular mass due to its diverse composition but is expressed throughout different tissues in the body. Its complexity and vast distribution are essential for maintaining tissue architecture and function.
Biological function summary

The extracellular matrix coordinates cellular functions by mediating mechanical and biochemical signals influencing cellular processes such as adhesion differentiation and migration. The ECM is an essential component of the matrix receptor complex interacting dynamically with cell-surface receptors like integrins. These interactions are important to tissue remodeling and repair allowing tissues to maintain homeostasis and respond to external stresses.

Pathways

The extracellular matrix participates in significant biological pathways like the integrin signaling pathway and the Wnt signaling pathway. These pathways link ECM to various cellular responses affecting processes such as cell migration proliferation and survival. Integrin proteins for example bind to ECM proteins transmitting signals that can regulate gene expression and determine cell fate. Disruption in these pathways has implications for developmental processes and disease states.

The extracellular matrix plays a role in conditions such as fibrosis and cancer. Alterations in ECM components or remodelling can lead to fibrotic diseases where excessive ECM deposition affects tissue function. In cancer ECM changes can influence tumor progression and metastasis. Matrix metalloproteinases (MMPs) a group of enzymes breaking down ECM proteins connect ECM to these pathological states altering tissue integrity and facilitating disease progression. Understanding ECM dynamics is therefore essential for developing therapeutic strategies against these disorders.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Carrier protein for platelet (but not plasma) factor V/Va. Plays a role in the storage and stabilization of factor V in platelets. Upon release following platelet activation, may limit platelet and plasma factor Va-dependent thrombin generation. Ligand for integrin alpha-IIb/beta-3 and integrin alpha-V/beta-3 on activated platelets, and may function as an extracellular matrix or adhesive protein.
See full target information MMRN1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Journal of thoracic disease 16:8363-8378 PubMed39831245

2025

Endoplasmic reticulum stress-MMRN1 positive feedback contributes to cisplatin resistance in small cell lung cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Mingxin Liu,Peihong Hu,Bo Tang,Qi Yang,Run Xiang,Yiqiang Liu,Juan Li,Binghuo Wu,Hong Wu,Bo Tian,Chuan Xu,Qiang Li
View all publications
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Product promise

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