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AB167224

Anti-EDA2R/XEDAR antibody

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(2 Publications)

Mouse Polyclonal EDA2R/XEDAR antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human EDA2R.

View Alternative Names

TNFRSF27, XEDAR, UNQ2448/PRO5727/PRO34080, EDA2R, Tumor necrosis factor receptor superfamily member 27, X-linked ectodysplasin-A2 receptor, EDA-A2 receptor

1 Images
Western blot - Anti-EDA2R/XEDAR antibody (AB167224)
  • WB

Unknown

Western blot - Anti-EDA2R/XEDAR antibody (AB167224)

All lanes:

Western blot - Anti-EDA2R/XEDAR antibody (ab167224) at 1 µg/mL

Lane 1:

EDA2R/XEDAR Transfected 293T cell lysate at 15 µg

Lane 2:

Non transfected 293T cell lysate at 15 µL

Predicted band size: 33 kDa

false

Key facts

Host species

Mouse

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human EDA2R.

Q9HAV5

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Alternative Products

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AB203667

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-EDA2R/XEDAR antibody (AB203667)

  • 0
  • 0

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Primary Antibodies

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Primary Antibodies

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p></p>" }, "Chimpanzee": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Common marmoset": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Gorilla": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Macaque monkey": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Orangutan": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rabbit": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The EDA2R also known as XEDAR (X-linked Ectodermal Dysplasia Receptor) is a member of the tumor necrosis factor receptor superfamily. This protein has a mass of approximately 42 kDa. EDA2R is expressed widely in various tissues including the skin hair follicles and glands. Its mechanical role involves binding to specific members of the ectodysplasin family mediating downstream signaling.
Biological function summary

The EDA2R protein engages in ectodermal development processes. It is involved in the formation of skin hair and sweat glands. EDA2R functions by activating signaling pathways that regulate cell development and differentiation. Though primarily a solo actor it interacts with other molecules to carry out its biological actions effectively.

Pathways

EDA2R is actively involved in the NF-kappa B signaling pathway and may intersect with the Wnt signaling pathway. These pathways influence various cellular responses like inflammation and cell growth. EDA2R shares functional pathways with proteins such as EDAR and EDARADD which facilitate the signals through similar or connected mechanisms in the organization of ectodermal structures.

EDA2R has been specifically associated with ectodermal dysplasia a group of disorders affecting skin hair and glands. Mutations or malfunctions in EDA2R can lead to abnormal developments in these tissues. EDA2R also shows relevance in certain cancers where its expression level can impact tumor growth and survival. In both contexts EDAR is a connected protein that often partners with EDA2R to influence disease progression.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Receptor for EDA isoform A2, but not for EDA isoform A1. Mediates the activation of the NF-kappa-B and JNK pathways. Activation seems to be mediated by binding to TRAF3 and TRAF6.
See full target information EDA2R
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Experimental animals 73:376-389 PubMed38797667

2024

Ectodysplasin-A2 receptor (EDA2R) knockdown alleviates myocardial ischemia/reperfusion injury through inhibiting the activation of the NF-κB signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Zhi-Hui Guan,Di Yang,Yi Wang,Jia-Bin Ma,Guo-Nian Wang

The Journal of nutritional biochemistry 129:109636 PubMed38561079

2024

A grape-supplemented diet prevented ultraviolet (UV) radiation-induced cataract by regulating Nrf2 and XIAP pathways.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaobin Liu,Yu Yu,Luís Aguilera Garcia,My-Lien Au,Myhoa Tran,Jinmin Zhang,Alexander Lou,Yang Liu,Hongli Wu
View all publications
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Product promise

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