AB203667

Anti-EDA2R/XEDAR antibody

Name: Anti-EDA2R/XEDAR antibody (ab203667) | Abcam
Brand: Abcam Limited
SKU: AB203667

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(3 Publications)

Rabbit Polyclonal EDA2R/XEDAR antibody. Suitable for IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human EDA2R aa 50-150 conjugated to Keyhole Limpet Haemocyanin.

View Alternative Names

TNFRSF27, XEDAR, UNQ2448/PRO5727/PRO34080, EDA2R, Tumor necrosis factor receptor superfamily member 27, X-linked ectodysplasin-A2 receptor, EDA-A2 receptor

1 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-EDA2R/XEDAR antibody (AB203667)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-EDA2R/XEDAR antibody (AB203667)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human gastric carcinoma tissue labeling EDA2R/XEDAR with ab203667 at 1/200 dilution, followed by conjugation to the secondary antibody and DAB staining.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human EDA2R aa 50-150 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

Q9HAV5

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/500", "IHCP-species-notes": "<p>(or 1/50 - 1/200 using a fluorescent secondary antibody).</p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein A

Storage buffer

pH: 7.4 Preservative: 0.02% Proclin 300 Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The EDA2R also known as XEDAR (X-linked Ectodermal Dysplasia Receptor) is a member of the tumor necrosis factor receptor superfamily. This protein has a mass of approximately 42 kDa. EDA2R is expressed widely in various tissues including the skin hair follicles and glands. Its mechanical role involves binding to specific members of the ectodysplasin family mediating downstream signaling.

Biological function summary

The EDA2R protein engages in ectodermal development processes. It is involved in the formation of skin hair and sweat glands. EDA2R functions by activating signaling pathways that regulate cell development and differentiation. Though primarily a solo actor it interacts with other molecules to carry out its biological actions effectively.

Pathways

EDA2R is actively involved in the NF-kappa B signaling pathway and may intersect with the Wnt signaling pathway. These pathways influence various cellular responses like inflammation and cell growth. EDA2R shares functional pathways with proteins such as EDAR and EDARADD which facilitate the signals through similar or connected mechanisms in the organization of ectodermal structures.

EDA2R has been specifically associated with ectodermal dysplasia a group of disorders affecting skin hair and glands. Mutations or malfunctions in EDA2R can lead to abnormal developments in these tissues. EDA2R also shows relevance in certain cancers where its expression level can impact tumor growth and survival. In both contexts EDAR is a connected protein that often partners with EDA2R to influence disease progression.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Receptor for EDA isoform A2, but not for EDA isoform A1. Mediates the activation of the NF-kappa-B and JNK pathways. Activation seems to be mediated by binding to TRAF3 and TRAF6.

See full target information EDA2R

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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

The American journal of pathology 195:1376-1393 PubMed40451321

2025

Exploratory Study of Prognostic Plasma Biomarkers in Patients with Pulmonary Arterial Hypertension.

Applications

Unspecified application

Species

Unspecified reactive species

Yukimitsu Kuwabara,Tetsuro Yokokawa,Sarah-Eve Lemay,Mélanie Sauvaget,Sandra Martineau,Sandra Breuils-Bonnet,François Potus,Sébastien Bonnet,Steeve Provencher,Olivier Boucherat

ACS omega 9:21838-21850 PubMed38799363

2024

Activation of GPR55 Ameliorates Maternal Separation-Induced Learning and Memory Deficits by Augmenting 5-HT Synthesis in the Dorsal Raphe Nucleus of Juvenile Mice.

Applications

Unspecified application

Species

Unspecified reactive species

Ting Sun,Ya-Ya Du,Yong-Qiang Zhang,Qin-Qin Tian,Xi Li,Jiao-Yan Yu,Yan-Yan Guo,Qing-Qing Liu,Le Yang,Yu-Mei Wu,Qi Yang,Ming-Gao Zhao

Biochimie 174:74-83 PubMed32304771

2020

EDA2R mediates podocyte injury in high glucose milieu.

Applications

Unspecified application

Species

Unspecified reactive species

Xiqian Lan,Vinod Kumar,Alok Jha,Rukhsana Aslam,Haichao Wang,Kehong Chen,Yueming Yu,Weimei He,Feilan Chen,Huairong Luo,Ashwani Malhotra,Pravin C Singhal

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-EDA2R/XEDAR antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-EDA2R/XEDAR antibody (AB203667)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Alternative Products

Primary Antibodies

Complementary Products

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (3)

Product promise