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AB251961

Anti-EDG6/S1PR4 antibody

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(1 Publication)

Rabbit Polyclonal EDG6/S1PR4 antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human S1PR4 aa 1-50.

View Alternative Names

EDG6, S1PR4, Sphingosine 1-phosphate receptor 4, S1P receptor 4, S1P4, Endothelial differentiation G-protein coupled receptor 6, Sphingosine 1-phosphate receptor Edg-6, S1P receptor Edg-6

1 Images
Immunocytochemistry/ Immunofluorescence - Anti-EDG6/S1PR4 antibody (AB251961)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-EDG6/S1PR4 antibody (AB251961)

PFA-fixed, Triton X-100 permeabilized U-2 OS (human bone osteosarcoma epithelial cell line) cells stained for EDG6/S1PR4 (green) using ab251961 at 4 μg/ml in ICC/IF.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human S1PR4 aa 1-50. The exact immunogen used to generate this antibody is proprietary information.

O95977

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100.</p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

EDG6 also known as S1PR4 is a G protein-coupled receptor that specifically binds sphingosine 1-phosphate (S1P). It has a molecular mass of approximately 42 kDa. It is mostly expressed in lymphoid tissues including the spleen and thymus as well as in certain blood cells like lymphocytes. S1PR4 plays a role in regulating immune cell behavior by influencing their migration proliferation and survival processes.
Biological function summary

S1PR4 impacts immune cell signaling and homeostasis. The receptor is a part of the sphingosine 1-phosphate receptor complex family which includes several other receptors like S1PR1 S1PR2 S1PR3 and S1PR5. S1PR4's activity affects lymphocyte circulation and localization playing a part in immune surveillance and response. Its expression pattern suggests importance in the adaptive immune system's regulation through intricate cellular signaling mechanisms.

Pathways

S1PR4 integrates into the S1P signaling pathway and the immune system signaling network. It interacts with proteins such as S1PR1 and S1PR3 contributing to the regulation of immune cell trafficking and vascular stability. These pathways help mediate immune response escalation or dampening as well as maintaining lymphatic endothelial barrier function. Such pathways emphasize S1PR4's role in controlling immune and vascular systems.

S1PR4 involvement suggests a link to autoimmune disorders and lymphomas. In autoimmune disorders abnormal S1P signaling through S1PR4 may result in improper lymphocyte migration contributing to disease progression. In lymphomas S1PR4 expression and interaction with other proteins like S1PR1 can influence tumor cell trafficking and survival. Understanding S1PR4's network offers potential therapeutic opportunities for these conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

G protein-coupled receptor highly expressed in immune cells, where it regulates immune response and cytokine production. Functions as a receptor for the lysosphingolipid sphingosine-1-phosphate (S1P). Upon S1P binding, promotes regulatory T-cell differentiation and enhances fatty acid oxidation, through activation of the NRF2/PPARA signaling pathway (By similarity). Modulates also M1 macrophage activation through interaction with FPR2 and the JNK signaling, contributing to the inflammatory response (By similarity). In addition, facilitates early neutrophil mobilization and vascular activation during inflammation, promoting lymphocyte recruitment to draining lymph nodes and supporting the development of germinal centers for an effective adaptive immune response (By similarity).
See full target information S1PR4
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Molecular cancer 20:115 PubMed34496885

2021

An ADAR1-dependent RNA editing event in the cyclin-dependent kinase CDK13 promotes thyroid cancer hallmarks.

Applications

Unspecified application

Species

Unspecified reactive species

Julia Ramírez-Moya,Christos Miliotis,Allison R Baker,Richard I Gregory,Frank J Slack,Pilar Santisteban
View all publications
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Product promise

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