AB88667

Anti-EDIL3/DEL1 antibody [4C9]

Name: Anti-EDIL3/DEL1 antibody [4C9] (ab88667) | Abcam
Brand: Abcam Limited
SKU: AB88667
Price: 715 USD
Availability: InStock
Rating: 5 (2 reviews)

(2 Reviews)

(4 Publications)

Mouse Monoclonal EDIL3/DEL1 antibody. Suitable for WB and reacts with Recombinant fragment - Human, Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human EDIL3 aa 100-200.

View Alternative Names

DEL1, EDIL3, EGF-like repeat and discoidin I-like domain-containing protein 3, Developmentally-regulated endothelial cell locus 1 protein, Integrin-binding protein DEL1

2 Images

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Western blot - Anti-EDIL3/DEL1 antibody [4C9] (AB88667)

This image was generated using the ascites version of the product.

All lanes:

Western blot - Anti-EDIL3/DEL1 antibody [4C9] (ab88667) at 5 µg/mL

All lanes:

human pancreas tissue lysate at 50 µg

Predicted band size: 54 kDa

Observed band size: 54 kDa

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Western blot - Anti-EDIL3/DEL1 antibody [4C9] (AB88667)

Western blot against tagged recombinant protein immunogen. Predicted band size of immunogen is 37 kDa.

This image was generated using the ascites version of the product.

All lanes:

Western blot - Anti-EDIL3/DEL1 antibody [4C9] (ab88667) at 5 µg/mL

All lanes:

Partial tagged recombinant human EDIL3/DEL1 protein (the immunogen) at 0.2 µg

Predicted band size: 54 kDa

Observed band size: 37 kDa

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Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

4C9

Isotype

IgG2a

Light chain type

kappa

Carrier free

Reacts with

Human

Applications

applications

Immunogen

Recombinant Fragment Protein within Human EDIL3 aa 100-200. The exact immunogen used to generate this antibody is proprietary information.

O43854

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Orangutan": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Recombinant fragment - Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>" }, "Xenopus laevis": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Zebrafish": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }

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Product details

This product was changed from ascites to tissue culture supernatant on 30^th April 2019. Please note that the dilutions may need to be adjusted accordingly. If you have any questions, please do not hesitate to contact our scientific support team.

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Properties and storage information

Form

Liquid

Purity

Tissue culture supernatant

Purification technique

Affinity purification Protein A

Storage buffer

pH: 7.4 Constituents: PBS

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The protein EDIL3 also known as DEL1 or del-1 protein is a secreted extracellular matrix protein with a mass of approximately 52 kDa. It is expressed highly in endothelial cells and has a significant presence during embryonic development particularly within the arteries. As a versatile protein EDIL3 plays a role in promoting cell adhesion through interaction with integrins. This interaction makes it important for cellular communication and structural support in various tissues.

Biological function summary

EDIL3 influences vascular development and angiogenesis. It is not generally part of a large protein complex but works independently to support endothelial cell survival and proliferation. It binds preferentially to integrins like alphavbeta3 and alphavbeta5. This binding initiates intracellular signaling cascades that activate pathways responsible for cell growth and migration. EDIL3 therefore contributes to stabilizing newly formed blood vessels which is essential during developmental processes.

Pathways

EDIL3 plays a role in the regulation of several signaling networks including the MAPK and PI3K/AKT pathways. In these pathways it assists angiogenesis and endothelial cell function by activating signaling that promotes cell division and survival. EDIL3-related pathway interactions involve proteins such as VEGF an important factor in angiogenesis which also partners with integrins to enhance vascular development and repair processes.

EDIL3 has implications in cancer and inflammatory diseases. In cancer EDIL3 aids the formation of new blood vessels that supply nutrients to tumors promoting their growth and metastasis. It partners with the VEGF protein to enhance angiogenic processes in tumor environments. Inflammatory diseases such as rheumatoid arthritis show elevated levels of EDIL3 where it encourages pro-inflammatory responses through endothelial cell interactions. Here EDIL3 might interact with proteins involved in inflammatory pathways exacerbating disease progression.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Promotes adhesion of endothelial cells through interaction with the alpha-v/beta-3 integrin receptor. Inhibits formation of vascular-like structures. May be involved in regulation of vascular morphogenesis of remodeling in embryonic development.

See full target information EDIL3

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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Communications biology 5:660 PubMed35787656

2022

Nano pom-poms prepared exosomes enable highly specific cancer biomarker detection.

Applications

Unspecified application

Species

Unspecified reactive species

Nan He,Sirisha Thippabhotla,Cuncong Zhong,Zachary Greenberg,Liang Xu,Ziyan Pessetto,Andrew K Godwin,Yong Zeng,Mei He

PloS one 16:e0250254 PubMed33901217

2021

Identification of a novel non-invasive biological marker to overcome the shortcomings of PSA in diagnosis and risk stratification for prostate cancer: Initial prospective study of developmental endothelial locus-1 protein.

Applications

Unspecified application

Species

Unspecified reactive species

Jae-Wook Chung,Hyun Tae Kim,Yun-Sok Ha,Eun Hye Lee,So Young Chun,Chan-Hyeong Lee,Kyeong Hyeon Byeon,Seock Hwan Choi,Jun Nyung Lee,Bum Soo Kim,Tae-Hwan Kim,Eun Sang Yoo,Ghil Suk Yoon,Moon-Chang Baek,Tae Gyun Kwon

Nature communications 10:1387 PubMed30918259

2019

Sulfisoxazole inhibits the secretion of small extracellular vesicles by targeting the endothelin receptor A.

Applications

Unspecified application

Species

Unspecified reactive species

Eun-Ju Im,Chan-Hyeong Lee,Pyong-Gon Moon,Gunassekaran Gowri Rangaswamy,Byungheon Lee,Jae Man Lee,Jae-Chul Lee,Jun-Goo Jee,Jong-Sup Bae,Taeg-Kyu Kwon,Keon-Wook Kang,Myeong-Seon Jeong,Joo-Eun Lee,Hyun-Suk Jung,Hyun-Joo Ro,Sangmi Jun,Wonku Kang,Seung-Yong Seo,Young-Eun Cho,Byoung-Joon Song,Moon-Chang Baek

Clinical cancer research : an official journal of the American Association for Cancer Research 22:1757-66 PubMed26603257

2015

Identification of Developmental Endothelial Locus-1 on Circulating Extracellular Vesicles as a Novel Biomarker for Early Breast Cancer Detection.

Applications

Unspecified application

Species

Unspecified reactive species

Pyong-Gon Moon,Jeong-Eun Lee,Young-Eun Cho,Soo Jung Lee,Jin Hyang Jung,Yee Soo Chae,Han-Ik Bae,Young-Bum Kim,In-San Kim,Ho Yong Park,Moon-Chang Baek

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-EDIL3/DEL1 antibody [4C9]

Western blot - Anti-EDIL3/DEL1 antibody [4C9] (AB88667)

Western blot - Anti-EDIL3/DEL1 antibody [4C9] (AB88667)

Key facts

Host species

Clonality

Clone number

Isotype

Light chain type

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Product details

Properties and storage information

Form

Purity

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (4)

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